THE STIMULATING EFFECT OF B-GLUCAN ON PROLACTIN SECRETION AND MORPHOLOGY IN GH3/B6 CELLS

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DELFI L.; SEPEHRI H.; RASOULI Y.; KHOUEI SAMIDEH

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Journal: IRANIAN JOURNAL OF BIOLOGY Year:2006 | Volume:19 | Issue:3 Page(s): 272-281

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Title

THE STIMULATING EFFECT OF B-GLUCAN ON PROLACTIN SECRETION AND MORPHOLOGY IN GH3/B6 CELLS

Author(s)

DELFI L. | SEPEHRI H. | RASOULI Y. | KHOUEI SAMIDEH | Issue Writer Certificate

Keywords

POLYSACCHARIDEQ2

PECTINQ2

Β-GLUCANQ3

GH3/B6 CELLSQ3

PROLACTINQ3

Abstract

The main active compounds of Lactogen herbal extracts are PECTIN and Β-GLUCAN which are POLYSACCHARIDE structure. Studies on the effect of these substances on hypophysis fragments indicated their potential to increase PROLACTIN secretion. In the present study, we used GH3/B6 cell line which is known to secret PROLACTIN and growth hormone. Western blotting following band densitometry via Total lab software showed PROLACTIN amount in the presence of b-glucan. In our study GH3/B6 CELLS were treated with various concentration of b-glucan ranging from 50 to 300 µgr/ml for a time period of 24 hours or 48 hours. b-glucan effect on PROLACTIN secretion was compared to control cells (in the absence of Β-GLUCAN) and positive control cells treated with 50 nM of Thyrotropine Releasing Hormone (TRH). TRH is one of the best PROLACTIN secretion stimulator in anterior hypophysis cells. These results indicate that 24 hours incubation of these cells in the presence of 50, 100, 200 µgr/ml (p<0.01) and 300 µgr/ml (p<0.05) of b-glucan can significantly increase PROLACTIN secretion in comparison with control. In 48 hours incubation with b-glucan, PROLACTIN secretion was significantly increased in 100, 300 (p<0.05) and 200 µgr/ml (p<0.01) in comparison with the control. In addition, phase contrast microscopy showed increased appearance of secretory granules which could correlate with increased PROLACTIN secretion.

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APA: Copy

DELFI, L., SEPEHRI, H., RASOULI, Y., & KHOUEI, SAMIDEH. (2006). THE STIMULATING EFFECT OF B-GLUCAN ON PROLACTIN SECRETION AND MORPHOLOGY IN GH3/B6 CELLS. IRANIAN JOURNAL OF BIOLOGY, 19(3), 272-281. SID. https://sid.ir/paper/21378/en

Vancouver: Copy

DELFI L., SEPEHRI H., RASOULI Y., KHOUEI SAMIDEH. THE STIMULATING EFFECT OF B-GLUCAN ON PROLACTIN SECRETION AND MORPHOLOGY IN GH3/B6 CELLS. IRANIAN JOURNAL OF BIOLOGY[Internet]. 2006;19(3):272-281. Available from: https://sid.ir/paper/21378/en

IEEE: Copy

L. DELFI, H. SEPEHRI, Y. RASOULI, and SAMIDEH KHOUEI, “THE STIMULATING EFFECT OF B-GLUCAN ON PROLACTIN SECRETION AND MORPHOLOGY IN GH3/B6 CELLS,” IRANIAN JOURNAL OF BIOLOGY, vol. 19, no. 3, pp. 272–281, 2006, [Online]. Available: https://sid.ir/paper/21378/en

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