THE EFFECT OF RETINOIC ACID ALVEOLAR MACROPHAGES

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RABANI CHADEGANI A.; FARAVARDEH L.; MORSHEDI D.

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Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF BIOLOGY Year:2001 | Volume:10 | Issue:1-2 Page(s): 22-30

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Information Journal Paper

Title

THE EFFECT OF RETINOIC ACID ALVEOLAR MACROPHAGES

Author(s)

RABANI CHADEGANI A. | FARAVARDEH L. | MORSHEDI D. | Issue Writer Certificate

Keywords

RETINOIC ACIDQ3

MACROPHAGEQ4

APOPTPSISQ4

Abstract

RETINOIC ACID is an active metabolite of retinoid involved in many metabolic functions of the cells. In this study the effect of all –trans RETINOIC ACID on alveolar MACROPHAGE viability, DNA fragmentation and superoxide anion production was investigated. The results show that the effects of RETINOIC ACID are dose dependent. At low concentrations, it increases the viability of MACROPHAGEs and at high concentrations it reduces viability. The maximum increase is seen at 10-7 M RETINOIC ACID. Analysis of extracted DNA from the treated and controls demonstrates that RETINOIC ACID prevents DNA fragmentation at low concentrations. However, at high values DNA fragmentation increases. Increase in superoxide anion production is also seen after short periods in cell culture. These results together with the determination of protein content of the treated and the control group and the cytological examination of the cells reveal that RETINOIC ACID directs MACROPHAGEs through apoptosis in a dose dependent manner.

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APA: Copy

RABANI CHADEGANI, A., FARAVARDEH, L., & MORSHEDI, D.. (2001). THE EFFECT OF RETINOIC ACID ALVEOLAR MACROPHAGES. IRANIAN JOURNAL OF BIOLOGY, 10(1-2), 22-30. SID. https://sid.ir/paper/21479/en

Vancouver: Copy

RABANI CHADEGANI A., FARAVARDEH L., MORSHEDI D.. THE EFFECT OF RETINOIC ACID ALVEOLAR MACROPHAGES. IRANIAN JOURNAL OF BIOLOGY[Internet]. 2001;10(1-2):22-30. Available from: https://sid.ir/paper/21479/en

IEEE: Copy

A. RABANI CHADEGANI, L. FARAVARDEH, and D. MORSHEDI, “THE EFFECT OF RETINOIC ACID ALVEOLAR MACROPHAGES,” IRANIAN JOURNAL OF BIOLOGY, vol. 10, no. 1-2, pp. 22–30, 2001, [Online]. Available: https://sid.ir/paper/21479/en

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