LEBER HEREDITARY OPTIC NEUROPATHY: DOSE FOLATE PATHWAY GENE ALTERATIONS INFLUENCE THE EXPRESSION OF MITOCHONDRIAL DNA MUTATION?

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ALEYASIN A.; GHAZANFARI M.; HOUSHMAND M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF BIOLOGY Year:2011 | Volume:24 | Issue:3 Page(s): 320-327

Download Full-Text

Persian Verion

View:

2,023

Download:

Cites:

Information Journal Paper

Title

LEBER HEREDITARY OPTIC NEUROPATHY: DOSE FOLATE PATHWAY GENE ALTERATIONS INFLUENCE THE EXPRESSION OF MITOCHONDRIAL DNA MUTATION?

Author(s)

ALEYASIN A. | GHAZANFARI M. | HOUSHMAND M. | Issue Writer Certificate

Keywords

LHONQ2

MTHFRQ2

MTRRQ2

FOLATEQ2

FOLIC ACIDQ2

Abstract

Leber hereditary optic neuropathy (LHON) is an inherited form of bilateral optic atrophy and loss of central vision. The primary cause of vision loss is mutation in the mtDNA however unknown secondary genetic and/or epigenetic risk factors are suggested to influence its neuropathology. In this study FOLATE gene polymorphisms has examined as possible LHON secondary genetic risk factor in Iranian patients. Common polymorphisms in methylene tetrahydrofolate reductase (MTHFR) (C677T and A1298C) and methionine synthase reductase (MTRR) (A66G) genes have been tested in 21 LHON patients and 150 normal controls. Strong linkages have been observed between LHON syndrome and C677T of the MTHFR (P<0.001) and A66G of the MTRR (P<0.001) genes. However, no significant linkage was found between A1298C (P=0.69) of the MTHFR gene and LHON syndrome. This is the first study that shows MTHFR C677T and MTRR A66G polymorphisms play role in the etiology of LHON syndrome. This finding may help in better understanding of mechanisms involved in neural degeneration and vision loss of LHON and better treatment of patients.

Cites

No record.

References

No record.

Cite

APA: Copy

ALEYASIN, A., GHAZANFARI, M., & HOUSHMAND, M.. (2011). LEBER HEREDITARY OPTIC NEUROPATHY: DOSE FOLATE PATHWAY GENE ALTERATIONS INFLUENCE THE EXPRESSION OF MITOCHONDRIAL DNA MUTATION?. IRANIAN JOURNAL OF BIOLOGY, 24(3), 320-327. SID. https://sid.ir/paper/21587/en

Vancouver: Copy

ALEYASIN A., GHAZANFARI M., HOUSHMAND M.. LEBER HEREDITARY OPTIC NEUROPATHY: DOSE FOLATE PATHWAY GENE ALTERATIONS INFLUENCE THE EXPRESSION OF MITOCHONDRIAL DNA MUTATION?. IRANIAN JOURNAL OF BIOLOGY[Internet]. 2011;24(3):320-327. Available from: https://sid.ir/paper/21587/en

IEEE: Copy

A. ALEYASIN, M. GHAZANFARI, and M. HOUSHMAND, “LEBER HEREDITARY OPTIC NEUROPATHY: DOSE FOLATE PATHWAY GENE ALTERATIONS INFLUENCE THE EXPRESSION OF MITOCHONDRIAL DNA MUTATION?,” IRANIAN JOURNAL OF BIOLOGY, vol. 24, no. 3, pp. 320–327, 2011, [Online]. Available: https://sid.ir/paper/21587/en

Related Journal Papers