EVALUATION OF ADENOID CYSTIC CARCINOMA AND POLYMORPHOUS LOW-GRADE ADENOCARCINOMA BY IMMUNOHISTOCHEMISTRY

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SAGHRAVANIAN N.A.; MOHTASHAM N.; SHAKERI M.T.

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Journal: Journal of Dental School Year:2009 | Volume:26 | Issue:4 (78) Page(s): 355-362

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Title

EVALUATION OF ADENOID CYSTIC CARCINOMA AND POLYMORPHOUS LOW-GRADE ADENOCARCINOMA BY IMMUNOHISTOCHEMISTRY

Author(s)

SAGHRAVANIAN N.A. | MOHTASHAM N. | SHAKERI M.T. | Issue Writer Certificate

Keywords

ADENOID CYSTIC CARCINOMAQ3

POLYMORPHOUS LOW –GRADE ADENOCARCINOMAQ3

IMMUNOHISTOCHEMSTRYQ3

Abstract

Background and Aim: Salivary gland tumors classification continuously undergoes alternations, especially in the recent years. This study used immunohistochemical markers for distinguishing between polymorphous low-grade adenocarcinoma (PLGA) and adenocarcinoma carcinoma (AdCC) which have several overlapping histological and clinical features.Materials & Methods: Ten AdCC and eight PLGA with five normal minor salivary glands were selected after review by two oral pathologists. LSAB method was used for seven markers: carcinoembryonic antigen, epithelial membrane antigen, muscle specific actin, vimentin, S100, P53 and Ki-67. Finally, the data were analyzed by Mann-Whiteny test.Results: Analysis of data showed a high expression of CEA, EMA and Ki-67 in AdCC compared to PLGA. Although, CEA (P Less than 0.001) expression was limited to luminal cells .In contrast, MSA (P=0.034) expression in nonluminal cells, and Ki-67 (P Less than0.001) occurred in both luminal and nonluminal cells. Also there was highly expression of vimentin and S-100 in PLGA with no significancy for EMA and Tp53. Conclusion: The result of this study suggests that ICH can be a helpful tool. The immunostaining of AdCC and PLGA with CEA, Vimentin and Ki-67 were of greater significant, S100 and MSA were less significant and the others (EMA and P53) could not offer an adjunctive aid in differential diagnosis between the two tumors.

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APA: Copy

SAGHRAVANIAN, N.A., MOHTASHAM, N., & SHAKERI, M.T.. (2009). EVALUATION OF ADENOID CYSTIC CARCINOMA AND POLYMORPHOUS LOW-GRADE ADENOCARCINOMA BY IMMUNOHISTOCHEMISTRY. JOURNAL OF DENTAL SCHOOL SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCE, 26(4 (78)), 355-362. SID. https://sid.ir/paper/21864/en

Vancouver: Copy

SAGHRAVANIAN N.A., MOHTASHAM N., SHAKERI M.T.. EVALUATION OF ADENOID CYSTIC CARCINOMA AND POLYMORPHOUS LOW-GRADE ADENOCARCINOMA BY IMMUNOHISTOCHEMISTRY. JOURNAL OF DENTAL SCHOOL SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCE[Internet]. 2009;26(4 (78)):355-362. Available from: https://sid.ir/paper/21864/en

IEEE: Copy

N.A. SAGHRAVANIAN, N. MOHTASHAM, and M.T. SHAKERI, “EVALUATION OF ADENOID CYSTIC CARCINOMA AND POLYMORPHOUS LOW-GRADE ADENOCARCINOMA BY IMMUNOHISTOCHEMISTRY,” JOURNAL OF DENTAL SCHOOL SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCE, vol. 26, no. 4 (78), pp. 355–362, 2009, [Online]. Available: https://sid.ir/paper/21864/en

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