THE EFFECTS OF AEROBIC TRAINING ON EXPRESSION OF BCL-2 AND MIR-15 AND BCL-2 PROTEIN IN TUMOR TISSUE IN MICE WITH BREAST CANCER

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AMINI A.; GAEINI A.; CHOBINEH S.; KORDI M.R.; ALIZADEH S.

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Journal: SPORT PHYSIOLOGY (RESEARCH ON SPORT SCIENCE) Year:2017 | Volume:8 | Issue:32 Page(s): 85-100

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Information Journal Paper

Title

THE EFFECTS OF AEROBIC TRAINING ON EXPRESSION OF BCL-2 AND MIR-15 AND BCL-2 PROTEIN IN TUMOR TISSUE IN MICE WITH BREAST CANCER

Author(s)

Keywords

BREAST CANCERQ2

AEROBIC TRAININGQ2

MIR-15Q1

BCL-2Q1

Abstract

Aerobic training reduces BREAST CANCER tumor growth. This study evaluated the expression of BCL-2, MIR-15, and BCL-2 protein as a positive mechanism induced by AEROBIC TRAINING. Twenty BALB/c mice (5–6 weeks, 16–17 g) were injected with MC4-L2 mammary cancer cells. Then, they were randomly divided to exercise and control groups (n=10) and 48 hours after the last exercise session, they were scarified and blood and tissue samples were collected and stored in -70oC. Expression of MIR-15 and BCL-2 were analyzed with Real- time PCR and ELISA. The expression level of BCL-2 gene and protein as well as and tumor growth were significantly decreased in exercise group compared with control group (P<0.001). Also, MIR-15 expression increased significantly in exercise group compared with control group (P<0.001). Overall, it seems that overexpression of MIR-15 and decreased expression of BCL-2 gene and protein induced by aerobic exercise training was effective in reducing tumor growth rate.a

Cites

Effect of Six Weeks of Interval Exercise Training along with Selenium Nanoparticle Ingestion on Bcl-2 and LC3 Genes expression in the Tumor Tissue of Breast Tumor– Bearing Mice

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APA: Copy

AMINI, A., GAEINI, A., CHOBINEH, S., KORDI, M.R., & ALIZADEH, S.. (2017). THE EFFECTS OF AEROBIC TRAINING ON EXPRESSION OF BCL-2 AND MIR-15 AND BCL-2 PROTEIN IN TUMOR TISSUE IN MICE WITH BREAST CANCER. SPORT PHYSIOLOGY (RESEARCH ON SPORT SCIENCE), 8(32 ), 85-100. SID. https://sid.ir/paper/228302/en

Vancouver: Copy

AMINI A., GAEINI A., CHOBINEH S., KORDI M.R., ALIZADEH S.. THE EFFECTS OF AEROBIC TRAINING ON EXPRESSION OF BCL-2 AND MIR-15 AND BCL-2 PROTEIN IN TUMOR TISSUE IN MICE WITH BREAST CANCER. SPORT PHYSIOLOGY (RESEARCH ON SPORT SCIENCE)[Internet]. 2017;8(32 ):85-100. Available from: https://sid.ir/paper/228302/en

IEEE: Copy

A. AMINI, A. GAEINI, S. CHOBINEH, M.R. KORDI, and S. ALIZADEH, “THE EFFECTS OF AEROBIC TRAINING ON EXPRESSION OF BCL-2 AND MIR-15 AND BCL-2 PROTEIN IN TUMOR TISSUE IN MICE WITH BREAST CANCER,” SPORT PHYSIOLOGY (RESEARCH ON SPORT SCIENCE), vol. 8, no. 32 , pp. 85–100, 2017, [Online]. Available: https://sid.ir/paper/228302/en

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