THE EFFECTS OF EXERCISE PRECONDITIONING ON THE LEVELS OF INTERLEUKIN-6 AND 10 IN CARDIAC TISSUE IN MICE WITH BREAST CANCER

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EBRAHIMPUR Z.; PEERI M.; MATIN HOMAEE H.; FARZANEGI P.

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Journal: Ebnesina Year:2017 | Volume:19 | Issue:2 (59) Page(s): 4-11

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Information Journal Paper

Title

THE EFFECTS OF EXERCISE PRECONDITIONING ON THE LEVELS OF INTERLEUKIN-6 AND 10 IN CARDIAC TISSUE IN MICE WITH BREAST CANCER

Author(s)

EBRAHIMPUR Z. | PEERI M. | MATIN HOMAEE H. | FARZANEGI P. | Issue Writer Certificate

Keywords

AEROBIC EXERCISESQ3

INTERLEUKIN-6Q2

INTERLEUKIN-10Q2

BREAST CANCERQ3

MYOCARDIUMQ2

Abstract

Background: There is a high risk of mortality from cardiovascular diseases among women with BREAST CANCER. Aerobic exercise training is effective in preventing and survival of these diseases as well as prevention and treatment of BREAST CANCER. This study aimed to investigate the effects of exercise preconditioning on the levels of interleukin 6 (IL-6) and 10 (IL-10) in cardiac tissue in mice with BREAST CANCER.Materials and methods: The study was conducted on 56 BALB/c mice (female and 3-5 weeks old) with an average weight of 15-20 g which randomly divided into two groups of active and inactive ones. The active group swam for three weeks, three days a week and 30 minutes daily, in a water tank. After three weeks, a million tumor cells were injected into them. Both groups were separately divided into four subgroups: A) continued training group, B) stop exercise group, C) chemotherapy with doxorubicin, and D) exercise- doxorubicin group. Finally, the levels of IL-6 and 10 of cardiac tissue were determined as inflammatory and anti-inflammatory markers.Results: Findings showed a significant increase of IL-10 in the active group (in subgroups A and B (none-chemotherapy groups) compared to the passive group, while this difference did not exist between two main groups in subgroups C and D (chemotherapy groups). Despite the lack of a significant difference in training-chemotherapy subgroups (D), a greater increase of IL-10 among them than the group of chemotherapy alone was observed. Also, there was a significant reduction of IL-6 in the active group compared to the inactive which was observed in all subgroups.Conclusion: The results of this study showed that eight weeks of endurance swimming training before cancer may result in reducing inflammatory complications of cancer in mice with BREAST CANCER with increase and decrease in the levels of IL-10 and IL-6 in cardiac tissue, respectively.

Cites

The effectiveness of mindfulness-based cognitive therapy on interleukin 6 (IL-6) and biological age in female breast cancer patients

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APA: Copy

EBRAHIMPUR, Z., PEERI, M., MATIN HOMAEE, H., & FARZANEGI, P.. (2017). THE EFFECTS OF EXERCISE PRECONDITIONING ON THE LEVELS OF INTERLEUKIN-6 AND 10 IN CARDIAC TISSUE IN MICE WITH BREAST CANCER. EBNESINA, 19(2 (59)), 4-11. SID. https://sid.ir/paper/228651/en

Vancouver: Copy

EBRAHIMPUR Z., PEERI M., MATIN HOMAEE H., FARZANEGI P.. THE EFFECTS OF EXERCISE PRECONDITIONING ON THE LEVELS OF INTERLEUKIN-6 AND 10 IN CARDIAC TISSUE IN MICE WITH BREAST CANCER. EBNESINA[Internet]. 2017;19(2 (59)):4-11. Available from: https://sid.ir/paper/228651/en

IEEE: Copy

Z. EBRAHIMPUR, M. PEERI, H. MATIN HOMAEE, and P. FARZANEGI, “THE EFFECTS OF EXERCISE PRECONDITIONING ON THE LEVELS OF INTERLEUKIN-6 AND 10 IN CARDIAC TISSUE IN MICE WITH BREAST CANCER,” EBNESINA, vol. 19, no. 2 (59), pp. 4–11, 2017, [Online]. Available: https://sid.ir/paper/228651/en

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