THE EFFECT OF OPIUM ADDICTION ON POSTOPERATIVE INTRAABDOMINAL ADHESION IN RAT

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VAHEDIAN ARDAKANI J.; BEHJATI H.R.

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Paper Information

Journal: Journal of Kerman University of Medical Sciences Year:2002 | Volume:9 | Issue:1 Page(s): 21-26

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Information Journal Paper

Title

THE EFFECT OF OPIUM ADDICTION ON POSTOPERATIVE INTRAABDOMINAL ADHESION IN RAT

Author(s)

VAHEDIAN ARDAKANI J. | BEHJATI H.R. | Issue Writer Certificate

Keywords

INTRAABDOMINAL ADHESIONQ4

OPIUMQ3

MORPHINEQ3

ADDICTIONQ2

LAPAROTOMYQ3

Abstract

Intraperitoneal adhesion formation is a major cause of intestinal obstruction and infertility. Previous abdominal or pelvic surgery is the most common causes of intraperitoneal adhesion formation. ADDICTION to OPIUM and MORPHINE is not only an important social and individual problem in the world but also affects human physiology and immune system. This randomized double-blind study was designed to investigate the effect of ADDICTION to MORPHINE and OPIUM on postoperative intraperitoneal adhesion formation in rats. 63 female rats were divided into three groups and maintained under routine laboratory conditions. There was no ADDICTION in control group. MORPHINE ADDICTION was induced by adding MORPHINE sulfate powder in drinking water (0.4 mg/kg for a duration of 28 days) and in OPIUM group by adding OPIUM tablets in drinking water as powder. After confirmation of ADDICTION by subcutaneous injection of naloxan all rats underwent LAPAROTOMY and the serosa of the cecum was scratched over a 5mm x 5mm area. The second LAPAROTOMY was performed on 30th postoperative day. The extent of intraperitoneal adhesions was quantified based on a scoring system modified by Swolin and the information's were analysed by chi-square test. The results showed a significant reduction of intraperitoneal adhesion in addicted group compared with nonaddicted group (P<0.05). It is concluded that ADDICTION to MORPHINE and OPIUM decreases postoperative intraperitoneal adhesion formation in rats.

Cites

EFFECTS OF MORPHINE DEPENDENCY ON BONE HEALING IN RAT

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APA: Copy

VAHEDIAN ARDAKANI, J., & BEHJATI, H.R.. (2002). THE EFFECT OF OPIUM ADDICTION ON POSTOPERATIVE INTRAABDOMINAL ADHESION IN RAT. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, 9(1), 21-26. SID. https://sid.ir/paper/230/en

Vancouver: Copy

VAHEDIAN ARDAKANI J., BEHJATI H.R.. THE EFFECT OF OPIUM ADDICTION ON POSTOPERATIVE INTRAABDOMINAL ADHESION IN RAT. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2002;9(1):21-26. Available from: https://sid.ir/paper/230/en

IEEE: Copy

J. VAHEDIAN ARDAKANI, and H.R. BEHJATI, “THE EFFECT OF OPIUM ADDICTION ON POSTOPERATIVE INTRAABDOMINAL ADHESION IN RAT,” JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, vol. 9, no. 1, pp. 21–26, 2002, [Online]. Available: https://sid.ir/paper/230/en

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