Molecular Docking and Bioinformatics Study of Rare Codons in the Lampyroidea maculata Luciferase Gene

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MORTAZAVI M.; HOSSEINKHANI S.; TORKZADEH MAHANI M.; LOTFI S.; EMAMZADEH R.

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Journal: JOURNAL OF BIOTECHNOLOGY Year:2020 | Volume:11 | Issue:1 Page(s): 145-154

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Title

Molecular Docking and Bioinformatics Study of Rare Codons in the Lampyroidea maculata Luciferase Gene

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Keywords

Lampyroidea maculateQ1

LuciferaseQ1

Rare CodonQ1

Substrate Binding SiteQ1

Abstract

The bioluminescence process is a widespread phenomenon in nature. The Luciferase enzymes are identified in some domains of life, but the Luciferases from the Lampyridae family are considered for biological applications. The molecular cloning of a new type of Iranian firefly Luciferase from Lampyroidea maculata was reported, previously. In this study, the Rare Codons of the Iranian insect Luciferase gene were analyzed using the computational databases as ATGme, RACC, LaTcOm, and Sherlocc. Also, the structural modeling process of this enzyme was performed. Next, the status of these Rare Codons in this structural model was evaluatedusing SPDBV 4. 10 and PyMOL 2. 3. 2 software. In the following, the Substrate Binding Site in the enzyme's active site was studied using the AutoDock Vina 1. 5. 4. By molecular modeling, some Rare Codons were identified that may have a critical role in the structure and function of this Luciferase. AutoDock Vina was used in the molecular docking that recognizes Asp531 that yield closely related to luciferin and AMP binding site. These bioinformatics analyzes play an important role in the design of new drugs.

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APA: Copy

MORTAZAVI, M., HOSSEINKHANI, S., TORKZADEH MAHANI, M., LOTFI, S., & EMAMZADEH, R.. (2020). Molecular Docking and Bioinformatics Study of Rare Codons in the Lampyroidea maculata Luciferase Gene. JOURNAL OF BIOTECHNOLOGY, 11(1 ), 145-154. SID. https://sid.ir/paper/231184/en

Vancouver: Copy

MORTAZAVI M., HOSSEINKHANI S., TORKZADEH MAHANI M., LOTFI S., EMAMZADEH R.. Molecular Docking and Bioinformatics Study of Rare Codons in the Lampyroidea maculata Luciferase Gene. JOURNAL OF BIOTECHNOLOGY[Internet]. 2020;11(1 ):145-154. Available from: https://sid.ir/paper/231184/en

IEEE: Copy

M. MORTAZAVI, S. HOSSEINKHANI, M. TORKZADEH MAHANI, S. LOTFI, and R. EMAMZADEH, “Molecular Docking and Bioinformatics Study of Rare Codons in the Lampyroidea maculata Luciferase Gene,” JOURNAL OF BIOTECHNOLOGY, vol. 11, no. 1 , pp. 145–154, 2020, [Online]. Available: https://sid.ir/paper/231184/en

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