Increased the genes expression of phenylpropanoid biosynthesis pathway and production of podophyllotoxin by chitosan in cell cultures of Linum album

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ESMAEILZADEH BAHABADI SEDIGHEH; SHARIFI MOZAFAR; BEHMANESH MEHRDAD

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Journal: JOURNAL OF BIOTECHNOLOGY Year:2013 | Volume:4 | Issue:1 Page(s): 57-64

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Title

Increased the genes expression of phenylpropanoid biosynthesis pathway and production of podophyllotoxin by chitosan in cell cultures of Linum album

Author(s)

ESMAEILZADEH BAHABADI SEDIGHEH | SHARIFI MOZAFAR | BEHMANESH MEHRDAD | Issue Writer Certificate

Keywords

gene expressionQ1

podophyllotoxinQ2

chitosan and linum albumQ2

Abstract

Linum album is an herbaceous and medicinal plant that has important lignan such as podophyllotoxin (PTOX). PTOX has antiviral and anticancer properties. Since the chemical synthesis of PTOX is an expensive process, production of PTOX using cell and cultures of linum species is a cost-effective alternative approach. Various strategies have been employed to increase the production of secondary metabolites in cell cultures. In this study, we have verified the effect of chitosan on cell growth, PTOX production in 1, 2, 3 and 5 days after treatment. Cells elicited with chitosan for 5 days yielded the highest amount of PTOX. To study mechanism of chitosan action, expression of phenylalanine ammonio-lyase (PAL), cinnamoyl-CoA reductase (CCR), cinnamyl alcohol dehydrogenase (CAD) and pinoresinol lariciresinol reductase (PLR) genes were investigated. The expression of genes were increased, reaching a peak at 3 day after treatment. Chitosan up-regulate the production of PTOX, by effecting on gene expression of PTOX biosynthesis pathway.

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APA: Copy

ESMAEILZADEH BAHABADI, SEDIGHEH, SHARIFI, MOZAFAR, & BEHMANESH, MEHRDAD. (2013). Increased the genes expression of phenylpropanoid biosynthesis pathway and production of podophyllotoxin by chitosan in cell cultures of Linum album. JOURNAL OF BIOTECHNOLOGY, 4(1 ), 57-64. SID. https://sid.ir/paper/231202/en

Vancouver: Copy

ESMAEILZADEH BAHABADI SEDIGHEH, SHARIFI MOZAFAR, BEHMANESH MEHRDAD. Increased the genes expression of phenylpropanoid biosynthesis pathway and production of podophyllotoxin by chitosan in cell cultures of Linum album. JOURNAL OF BIOTECHNOLOGY[Internet]. 2013;4(1 ):57-64. Available from: https://sid.ir/paper/231202/en

IEEE: Copy

SEDIGHEH ESMAEILZADEH BAHABADI, MOZAFAR SHARIFI, and MEHRDAD BEHMANESH, “Increased the genes expression of phenylpropanoid biosynthesis pathway and production of podophyllotoxin by chitosan in cell cultures of Linum album,” JOURNAL OF BIOTECHNOLOGY, vol. 4, no. 1 , pp. 57–64, 2013, [Online]. Available: https://sid.ir/paper/231202/en

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