Optimization of Preparation of PEG-PLGA Nanoparticles by Solvent Evaporation Method

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Ebrahimi Samani S.; ASGHARI S.M.; NADERIMANESH H.; HOSEINKHANI S.

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Journal: JOURNAL OF BIOTECHNOLOGY Year:2018 | Volume:9 | Issue:2 Page(s): 201-205

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Title

Optimization of Preparation of PEG-PLGA Nanoparticles by Solvent Evaporation Method

Author(s)

Ebrahimi Samani S. | ASGHARI S.M. | NADERIMANESH H. | HOSEINKHANI S. | Issue Writer Certificate

Keywords

poly(ethylene glycol)Q1

blockQ1

lactideQ1

glycolideQ1

Solvent Evaporation MethodQ1

drug carrierQ1

Abstract

Aims: Among different nanosystems, polymeric nanoparticles are highly regarded because of their potential to be used as drug carrier. poly(ethylene glycol)-block-lactide-glycolide (PEG-PLGA) is an amphiphilic copolymer that can be used to carry water-soluble drugs and drugs and molecules insoluble in water. PEG-PLGA polymeric nanoparticles can reduce renal filtration and drug toxicity; they are also biodegradable and biocompatible. The aim of this study was to optimize preparation of PEG-PLGA nanoparticles by Solvent Evaporation Method. Materials & Methods: In the present experimental study, PEG-PLGA nanoparticles with a diameter of 150nm and a zeta potential of-10 were prepared by Solvent Evaporation Method. Then, the physicochemical properties of nanoparticles were carefully examined. Findings: By increasing the polymer concentration and the percentage of polyvinyl alcohol, particle size increased. The production of nanoparticles with a concentration of 5mg/ml copolymer, a 2% w/v polyvinyl alcohol concentration, and in a 12: 1 volume ratio showed the best size and superficial load. Morphologically, the nanoparticles were structurally similar and spherical. According to the FTIR spectrum, the peak in 2900-13000cm region was in accordance with the tensile bond C-H in CH3. A strong peak in 1760cm-1 was related to the tensile-CO that showed the copolymer formation. Conclusion: The production of PEG-PLGA nanoparticles in a concentration of 5mg/ml copolymer, 2% w/v of polyvinyl alcohol concentration, and in a 12: 1 volume ratio shows the best size and superficial load; also, the nanoparticles are structurally similar and spherical.

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APA: Copy

Ebrahimi Samani, S., ASGHARI, S.M., NADERIMANESH, H., & HOSEINKHANI, S.. (2018). Optimization of Preparation of PEG-PLGA Nanoparticles by Solvent Evaporation Method. JOURNAL OF BIOTECHNOLOGY, 9(2 ), 201-205. SID. https://sid.ir/paper/231285/en

Vancouver: Copy

Ebrahimi Samani S., ASGHARI S.M., NADERIMANESH H., HOSEINKHANI S.. Optimization of Preparation of PEG-PLGA Nanoparticles by Solvent Evaporation Method. JOURNAL OF BIOTECHNOLOGY[Internet]. 2018;9(2 ):201-205. Available from: https://sid.ir/paper/231285/en

IEEE: Copy

S. Ebrahimi Samani, S.M. ASGHARI, H. NADERIMANESH, and S. HOSEINKHANI, “Optimization of Preparation of PEG-PLGA Nanoparticles by Solvent Evaporation Method,” JOURNAL OF BIOTECHNOLOGY, vol. 9, no. 2 , pp. 201–205, 2018, [Online]. Available: https://sid.ir/paper/231285/en

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