THE EFFECT OF PRE-FEEDING FLAXSEED OIL (LINUM USITATISSIMUM) ON BLOOD BRAIN BARRIER PERMEABILITY IN RAT STROKE MODEL

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

HOSSEINI S.V.; RAHNEMA M.; BIGDELI M.R.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: EXPERIMENTAL ANIMAL BIOLOGY Year:2016 | Volume:4 | Issue:3 (15) Page(s): 13-20

Download Full-Text

Persian Verion

View:

719

Download:

Cites:

Information Journal Paper

Title

THE EFFECT OF PRE-FEEDING FLAXSEED OIL (LINUM USITATISSIMUM) ON BLOOD BRAIN BARRIER PERMEABILITY IN RAT STROKE MODEL

Author(s)

HOSSEINI S.V. | RAHNEMA M. | BIGDELI M.R. | Issue Writer Certificate

Keywords

FLAX SEED OILQ2

BLOOD-BRAIN BARRIERQ2

STROKEQ2

RATSQ2

Abstract

Ischemic Brain Edema is one of the most important complications of a STROKE. This study aims to investigate the impact of pre-feeding of FLAX SEED OIL on BLOOD-BRAIN BARRIER in rat STROKE model. In this experimental study animals were randomly divided into 3 groups of experiment, sham, and control. Each testing group itself was consisted of 3 subgroups receiving doses of Flaxseed oil with 0.25, 0.5 and 0.75 ml / kg of body weight for 30 days. The control group received distilled water, while therapy and ischemia induction were not done for sham group. In order to conduct ischemia induction and evaluating the permeability of the BLOOD-BRAIN BARRIER by measuring the optical density level of the Evans Blue MCAO (Middle Cerebral Artery Occlusion) model surgery was conducted on groups two hours after the last feeding dose. The data were analyzed via ANOVA test. The permeability decrease of the BLOOD-BRAIN BARRIER in groups with doses of 0.5 and 0.75 ml against the control group was statistically significant(P˂0.05). There were significant differences between the right and left hemispheres in control groups with dose of 0.25ml (P˂0.05).But the differences between the right and left hemispheres in therapy group with doses of 0.5 and 0.75 were insignificant. According to the findings of this study, pre-treatment with FLAX SEED OIL can reduce the permeability of the BLOOD-BRAIN BARRIER in a model of ischemia-reperfusion in RATS. But still more works to extend these observations including the investigation of neurological deficits are needed to be done.

Cites

No record.

References

No record.

Cite

APA: Copy

HOSSEINI, S.V., RAHNEMA, M., & BIGDELI, M.R.. (2016). THE EFFECT OF PRE-FEEDING FLAXSEED OIL (LINUM USITATISSIMUM) ON BLOOD BRAIN BARRIER PERMEABILITY IN RAT STROKE MODEL. EXPERIMENTAL ANIMAL BIOLOGY, 4(3 (15)), 13-20. SID. https://sid.ir/paper/236121/en

Vancouver: Copy

HOSSEINI S.V., RAHNEMA M., BIGDELI M.R.. THE EFFECT OF PRE-FEEDING FLAXSEED OIL (LINUM USITATISSIMUM) ON BLOOD BRAIN BARRIER PERMEABILITY IN RAT STROKE MODEL. EXPERIMENTAL ANIMAL BIOLOGY[Internet]. 2016;4(3 (15)):13-20. Available from: https://sid.ir/paper/236121/en

IEEE: Copy

S.V. HOSSEINI, M. RAHNEMA, and M.R. BIGDELI, “THE EFFECT OF PRE-FEEDING FLAXSEED OIL (LINUM USITATISSIMUM) ON BLOOD BRAIN BARRIER PERMEABILITY IN RAT STROKE MODEL,” EXPERIMENTAL ANIMAL BIOLOGY, vol. 4, no. 3 (15), pp. 13–20, 2016, [Online]. Available: https://sid.ir/paper/236121/en

Related Journal Papers