The necessity of urgent low-cost epidemiological studies with short duration about the role of BCG vaccine in preventing and controlling of COVID-19 in Iran

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PEZESHKI MOHAMMAD ZAKARIA; SHOJAEEFAR EHSAN

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Journal: Payesh Year:2020 | Volume:19 | Issue:2 Page(s): 139-144

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Title

The necessity of urgent low-cost epidemiological studies with short duration about the role of BCG vaccine in preventing and controlling of COVID-19 in Iran

Author(s)

PEZESHKI MOHAMMAD ZAKARIA | SHOJAEEFAR EHSAN | Issue Writer Certificate

Keywords

BCGQ3

tuberculin testQ2

COVID-19Q1

Type 1 diabetesQ3

Multiple sclerosisQ2

Ecological studyQ1

Abstract

Objective (s): Currently there is no effective treatment and vaccine for COVID-19. However, several studies showed that BCG vaccine has long lasting positive non-specific effects on several infectious and autoimmune diseases via ‘ trained immunity’ mechanisms. Along with these exceptional properties of this vaccine, few ecological studies showed controversial association between the national vaccination policies and morbidity and mortality rate of COVID-19. Methods: This Article, reviewed the immunological mechanisms that explain the enhanced immunity by BCG vaccine against COVID-19. Also the conducted ecological studies and the clinical trials that are being conducted by few countries were reviewed. Results: Considering Iran’ s national BCG vaccination program and the low evidence level of ecological studies, we suggest to Iranian universities of medical sciences to conduct low-cost but better epidemiological studies with short duration, using tuberculin test. These studies including case-control, historical cohort and survival analysis studies, which will assess the association between immunity against tuberculosis and COVID-19 and its prognosis. The results of these studies may guide researchers about the necessity of conducting clinical trials among high risk groups like hospital staffs. Conclusion: Also as few studies have shown BCG vaccine has therapeutic effects on patients with Type 1 diabetes and Multiple sclerosis, conducting clinical trials among Iranian patients can measure not only the preventive effect of BCG vaccine against COVID-19 but also the therapeutic effect on these two chronic diseases also.

Cites

آموزش مجازی، تجربه ای نوین و چالش برانگیز: پاندمی کرونا در محروم ترین استان کشور

References

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APA: Copy

PEZESHKI, MOHAMMAD ZAKARIA, & SHOJAEEFAR, EHSAN. (2020). The necessity of urgent low-cost epidemiological studies with short duration about the role of BCG vaccine in preventing and controlling of COVID-19 in Iran. PAYESH, 19(2 ), 139-144. SID. https://sid.ir/paper/23661/en

Vancouver: Copy

PEZESHKI MOHAMMAD ZAKARIA, SHOJAEEFAR EHSAN. The necessity of urgent low-cost epidemiological studies with short duration about the role of BCG vaccine in preventing and controlling of COVID-19 in Iran. PAYESH[Internet]. 2020;19(2 ):139-144. Available from: https://sid.ir/paper/23661/en

IEEE: Copy

MOHAMMAD ZAKARIA PEZESHKI, and EHSAN SHOJAEEFAR, “The necessity of urgent low-cost epidemiological studies with short duration about the role of BCG vaccine in preventing and controlling of COVID-19 in Iran,” PAYESH, vol. 19, no. 2 , pp. 139–144, 2020, [Online]. Available: https://sid.ir/paper/23661/en

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