EVALUATION OF INTERFERON-GAMMA APPLICATION FOR RECOGNITION OF PATIENTS AFFLICTED BY NON-HEALING CUTANEOUS LEISHMANIASIS

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MOAFI MOHAMMAD; REZVAN HOSSEIN; SHERKAT ROYA; ZARKESH ESFAHANI SAYYED HAMID; TALEBAN ROYA; ASILIAN ALI; NILFOROUSHZADEH MOHAMMAD ALI; JAFFARY FARIBA; MANSOURIAN MARJAN; SOKHANVARI FATEMEH; ANSARI NAZLI

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Journal: Journal of Microbial Biology Year:2017 | Volume:6 | Issue:22 Page(s): 101-112

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Title

EVALUATION OF INTERFERON-GAMMA APPLICATION FOR RECOGNITION OF PATIENTS AFFLICTED BY NON-HEALING CUTANEOUS LEISHMANIASIS

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Keywords

CUTANEOUS LEISHMANIASISQ1

INTERFERON-GAMMAQ1

LEISHMANINQ1

Abstract

Introduction: Different studies undertaken in the animal modeling show that INTERFERON-GAMMA deficiency impairs healing process of Leishmania infection. It seems that the level of INTERFERON-GAMMA production could also affect the healing duration of Leishmania lesion in humans. The current study aims to investigate the possibility of INTERFERON-GAMMA application for recognition of cases afflicted by non-healing Leishmaniasis.Materials and methods: Peripheral blood mononuclear cells (PBMCs) of 32 patients, who were afflicted by healing or non-healing Leishmaniasis, were isolated and the levels of INTERFERON-GAMMA were determined, using ELISA method. Afterwards, the cut-off point of INTERFERON-GAMMA to identify patients afflicted by non-healing Leishmaniasis was calculated through ROC-Curve analysis. Furthermore, LEISHMANIN Skin Test (LST) was performed for every patient.Results: Levels of INTERFERON-GAMMA produced by PBMCs stimulated with Soluble Leishmania Antigen (SLA) or Phytohemaglotinine were significantly higher in healing patients, compared with non-healing individuals (p <0.01). INTERFERON-GAMMA cut-off point in the optimized sensitivity (87.5%) and specificity (100%) was 1208 pg/ml. In addition, Levels of induration resulted from Lesihmanin Skin Test (LST) was significantly higher in healing patients, compared with healing individuals (p=0.023).Discussion and conclusion: INTERFERON-GAMMA deficiency could be considered as one of the causative factors in non-healing Leishmaniasis in humans. In fact, INTERFERON-GAMMA deficiency can identify some patients afflicted by non-healing Leishmaniasis.

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APA: Copy

MOAFI, MOHAMMAD, REZVAN, HOSSEIN, SHERKAT, ROYA, ZARKESH ESFAHANI, SAYYED HAMID, TALEBAN, ROYA, ASILIAN, ALI, NILFOROUSHZADEH, MOHAMMAD ALI, JAFFARY, FARIBA, MANSOURIAN, MARJAN, SOKHANVARI, FATEMEH, & ANSARI, NAZLI. (2017). EVALUATION OF INTERFERON-GAMMA APPLICATION FOR RECOGNITION OF PATIENTS AFFLICTED BY NON-HEALING CUTANEOUS LEISHMANIASIS. BIOLOGICAL JOURNAL OF MICROORGANISM, 6(22 ), 101-112. SID. https://sid.ir/paper/237417/en

Vancouver: Copy

MOAFI MOHAMMAD, REZVAN HOSSEIN, SHERKAT ROYA, ZARKESH ESFAHANI SAYYED HAMID, TALEBAN ROYA, ASILIAN ALI, NILFOROUSHZADEH MOHAMMAD ALI, JAFFARY FARIBA, MANSOURIAN MARJAN, SOKHANVARI FATEMEH, ANSARI NAZLI. EVALUATION OF INTERFERON-GAMMA APPLICATION FOR RECOGNITION OF PATIENTS AFFLICTED BY NON-HEALING CUTANEOUS LEISHMANIASIS. BIOLOGICAL JOURNAL OF MICROORGANISM[Internet]. 2017;6(22 ):101-112. Available from: https://sid.ir/paper/237417/en

IEEE: Copy

MOHAMMAD MOAFI, HOSSEIN REZVAN, ROYA SHERKAT, SAYYED HAMID ZARKESH ESFAHANI, ROYA TALEBAN, ALI ASILIAN, MOHAMMAD ALI NILFOROUSHZADEH, FARIBA JAFFARY, MARJAN MANSOURIAN, FATEMEH SOKHANVARI, and NAZLI ANSARI, “EVALUATION OF INTERFERON-GAMMA APPLICATION FOR RECOGNITION OF PATIENTS AFFLICTED BY NON-HEALING CUTANEOUS LEISHMANIASIS,” BIOLOGICAL JOURNAL OF MICROORGANISM, vol. 6, no. 22 , pp. 101–112, 2017, [Online]. Available: https://sid.ir/paper/237417/en

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