EVALUATION OF HER2/NEU GENE AMPLIFICATION FREQUENCY IN PATIENTS WITH GASTRIC CANCER USING MLPA METHOD

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LASHKARIZADEH MOHAMMAD REZA; BAZRAFSHANI MOHAMMADREZA; IZADI ALI; HOSSEINI FATEMESADAT

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Paper Information

Journal: JOURNAL OF TORBAT HEYDARIYEH UNIVERSITY OF MEDICAL SCIENCES Year:2015 | Volume:2 | Issue:4 Page(s): 38-45

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Title

EVALUATION OF HER2/NEU GENE AMPLIFICATION FREQUENCY IN PATIENTS WITH GASTRIC CANCER USING MLPA METHOD

Author(s)

LASHKARIZADEH MOHAMMAD REZA | BAZRAFSHANI MOHAMMADREZA | IZADI ALI | HOSSEINI FATEMESADAT | Issue Writer Certificate

Keywords

AMPLIFICATIONQ2

GENEQ2

HER2/NEUQ2

GASTRIC CANCERQ2

MLPA METHODQ2

Abstract

Background and aims: Gastric malignancies have the fourth place among the most prevalent cancers. In many cancers, overexpressing of HER2/NEU GENE has been observed with a poor prediction. Up to now, there is a little information about the duplication of HER2/NEU GENE in GASTRIC CANCER using MLPA METHOD. The present study aimed to investigate the frequency of mutations resulting from AMPLIFICATION of HER2/NEU GENE using MLPA technique in the patients with GASTRIC CANCER.Methods: This is a descriptive study which carried out on 60 samples of tissue block obtained from GASTRIC CANCER patients with endoscopic and surgical history between 1376-1391 years in Afzalipoor health centers to investigate the deletion and insertion mutations in HER2/NEU.Results: The study population consisted of 73.3% females and 26.7% males with the mean age of 62.71. Overall, the frequency of the AMPLIFICATION of HER2/NEU GENE in the low and high levels was 10% and 3.3%, respectively.Conclusion: It seems that, the AMPLIFICATION frequency of HER2/NEU GENE in men is more than women. However, it is recommended to conduct further studies.

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APA: Copy

LASHKARIZADEH, MOHAMMAD REZA, BAZRAFSHANI, MOHAMMADREZA, IZADI, ALI, & HOSSEINI, FATEMESADAT. (2015). EVALUATION OF HER2/NEU GENE AMPLIFICATION FREQUENCY IN PATIENTS WITH GASTRIC CANCER USING MLPA METHOD. JOURNAL OF TORBAT HEYDARIYEH UNIVERSITY OF MEDICAL SCIENCES, 2(4), 38-45. SID. https://sid.ir/paper/244657/en

Vancouver: Copy

LASHKARIZADEH MOHAMMAD REZA, BAZRAFSHANI MOHAMMADREZA, IZADI ALI, HOSSEINI FATEMESADAT. EVALUATION OF HER2/NEU GENE AMPLIFICATION FREQUENCY IN PATIENTS WITH GASTRIC CANCER USING MLPA METHOD. JOURNAL OF TORBAT HEYDARIYEH UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2015;2(4):38-45. Available from: https://sid.ir/paper/244657/en

IEEE: Copy

MOHAMMAD REZA LASHKARIZADEH, MOHAMMADREZA BAZRAFSHANI, ALI IZADI, and FATEMESADAT HOSSEINI, “EVALUATION OF HER2/NEU GENE AMPLIFICATION FREQUENCY IN PATIENTS WITH GASTRIC CANCER USING MLPA METHOD,” JOURNAL OF TORBAT HEYDARIYEH UNIVERSITY OF MEDICAL SCIENCES, vol. 2, no. 4, pp. 38–45, 2015, [Online]. Available: https://sid.ir/paper/244657/en

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