THE POSSIBILITY OF BONE CELL GROWTH (SAOS-2) ON THE COATED SCAFFOLDS WITH CHITOSAN- ALGINATE NANOPARTICLES

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NASSIRNIA H.; GHALAMBORAN M.R.; MEIMANDI POUR A.; BAYAT M.

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Journal: Journal of Molecular and Cellular Researches Year:2015 | Volume:28 | Issue:3 Page(s): 413-419

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Title

THE POSSIBILITY OF BONE CELL GROWTH (SAOS-2) ON THE COATED SCAFFOLDS WITH CHITOSAN- ALGINATE NANOPARTICLES

Author(s)

NASSIRNIA H. | GHALAMBORAN M.R. | MEIMANDI POUR A. | BAYAT M. | Issue Writer Certificate

Keywords

SCAFFOLDQ2

NANOPARTICLESQ1

ANTI BACTERIALQ2

OSTEOBLASTS CELLSQ1

Abstract

In recent years in Iran about 22, 000 deaths and 70, 000 injured due to traffic accidents happen, almost 92% of bone fractures and retriever has to refer to the restoration of bony orthopedic pathologies. Based on report from Shahid Beheshti University of medical sciences, about 85% of the bone marrow grafting due to the invasion of bacteria and fungi have been unsuccessful. As the use of SCAFFOLDing techniques suitable for reproduction and growth of cells and tissues, including strategies for restoration of the damaged tissue. However, the use of eco-compatible SCAFFOLDs in order to treat bone defects with a lot of challenges including a poor biocompatibility, low strength, low life expectancy of SCAFFOLDs cells due to invasion of bacteria and fungi have been met. In this regard, the main objectives of this research, investigating of cytotoxicity properties of coated SCAFFOLDs with chitosan–alginate NANOPARTICLES, review and compare the possibility of growth and life (viability) of bone cells on the SCAFFOLD without coating and coated with NANOPARTICLES. Results obtained showed that the bone cells growth on the coated SCAFFOLDs with NANOPARTICLES compared with uncoated SCAFFOLDs had a normal growth. As well as the amount of bone cells adhesion after 72 hours in normal shape to this SCAFFOLDs. Of the other hand, study on SCAFFOLDs structure with electron microscopic showed that coated SCAFFOLDs with chitosan-alginate NANOPARTICLES has a suitable size and porosity for the growth of osteoblast cells.

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APA: Copy

NASSIRNIA, H., GHALAMBORAN, M.R., MEIMANDI POUR, A., & BAYAT, M.. (2015). THE POSSIBILITY OF BONE CELL GROWTH (SAOS-2) ON THE COATED SCAFFOLDS WITH CHITOSAN- ALGINATE NANOPARTICLES. JOURNAL OF MOLECULAR AND CELLULAR RESEARCH (IRANIAN JOURNAL OF BIOLOGY), 28(3), 413-419. SID. https://sid.ir/paper/248467/en

Vancouver: Copy

NASSIRNIA H., GHALAMBORAN M.R., MEIMANDI POUR A., BAYAT M.. THE POSSIBILITY OF BONE CELL GROWTH (SAOS-2) ON THE COATED SCAFFOLDS WITH CHITOSAN- ALGINATE NANOPARTICLES. JOURNAL OF MOLECULAR AND CELLULAR RESEARCH (IRANIAN JOURNAL OF BIOLOGY)[Internet]. 2015;28(3):413-419. Available from: https://sid.ir/paper/248467/en

IEEE: Copy

H. NASSIRNIA, M.R. GHALAMBORAN, A. MEIMANDI POUR, and M. BAYAT, “THE POSSIBILITY OF BONE CELL GROWTH (SAOS-2) ON THE COATED SCAFFOLDS WITH CHITOSAN- ALGINATE NANOPARTICLES,” JOURNAL OF MOLECULAR AND CELLULAR RESEARCH (IRANIAN JOURNAL OF BIOLOGY), vol. 28, no. 3, pp. 413–419, 2015, [Online]. Available: https://sid.ir/paper/248467/en

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