EFFECT OF PECTIN SUBSTANCES ON NO RELEASE AND APOPTOSIS INDUCTION IN HUMAN PROSTATE CANCER CELLS LNCAP

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MANSOORI F.; SEPEHRI H.; DELPHI L.

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Journal: Journal of Animal Research Year:2017 | Volume:29 | Issue:4 Page(s): 480-492

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Title

EFFECT OF PECTIN SUBSTANCES ON NO RELEASE AND APOPTOSIS INDUCTION IN HUMAN PROSTATE CANCER CELLS LNCAP

Author(s)

MANSOORI F. | SEPEHRI H. | DELPHI L. | Issue Writer Certificate

Keywords

PECTINQ2

NITRIC OXIDEQ1

APOPTOSISQ1

LNCAP CELLSQ1

Abstract

PECTIN is a complex polysaccharide compound with food and anticancer properties. NO as a signaling molecule. It plays role in various physiological process. It may have pro or anti apoptotic role in cancer cells. In this research the effect of apple PECTIN (AP) and modified citrus PECTIN (MCP) on NO releasing and APOPTOSIS induction of human prostate cancer cell, LnCap, is under investigated. The cells were treated with different concentration of AP and MCP for 6, 24 and 48h. The amount of NO and proliferatin inhibition were studied. At first SNP treatment indicated that NO has an inhibitory role in LNCAP CELLS. The results showed that long term incubation of cells with AP and MCP caused significant changes in NO release and proliferation rate. Under this condition cell cycle arrested in Sub-G1 phase though APOPTOSIS was occurred. Therefore, AP and MCP could induce APOPTOSIS in LnCap cell via NO release.

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APA: Copy

MANSOORI, F., SEPEHRI, H., & DELPHI, L.. (2017). EFFECT OF PECTIN SUBSTANCES ON NO RELEASE AND APOPTOSIS INDUCTION IN HUMAN PROSTATE CANCER CELLS LNCAP. JOURNAL OF ANIMAL RESEARCH (IRANIAN JOURNAL OF BIOLOGY), 29(4), 480-492. SID. https://sid.ir/paper/248760/en

Vancouver: Copy

MANSOORI F., SEPEHRI H., DELPHI L.. EFFECT OF PECTIN SUBSTANCES ON NO RELEASE AND APOPTOSIS INDUCTION IN HUMAN PROSTATE CANCER CELLS LNCAP. JOURNAL OF ANIMAL RESEARCH (IRANIAN JOURNAL OF BIOLOGY)[Internet]. 2017;29(4):480-492. Available from: https://sid.ir/paper/248760/en

IEEE: Copy

F. MANSOORI, H. SEPEHRI, and L. DELPHI, “EFFECT OF PECTIN SUBSTANCES ON NO RELEASE AND APOPTOSIS INDUCTION IN HUMAN PROSTATE CANCER CELLS LNCAP,” JOURNAL OF ANIMAL RESEARCH (IRANIAN JOURNAL OF BIOLOGY), vol. 29, no. 4, pp. 480–492, 2017, [Online]. Available: https://sid.ir/paper/248760/en

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