Effect of sodium bicarbonate against Candida albicans in denture stomatitis: An in vitro study

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NAJAFI SHAMSOLMOULOUK; YAZDANI REZA; SALARI BEHZAD; Forouhesh Tehrani Homa; KHARRAZI FARD MOHAMMAD JAVAD

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Journal: Journal of Dental Medicine Year:2016 | Volume:29 | Issue:2 Page(s): 92-100

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Title

Effect of sodium bicarbonate against Candida albicans in denture stomatitis: An in vitro study

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Keywords

Sodium bicarbonateQ1

ChlorhexidineQ2

NystatinQ2

Candida albicansQ2

Denture stomatitisQ2

Abstract

Background and Aims: The aim of this study was to investigate the effects of Sodium bicarbonate against Candida albicans, the main infectious factor of Denture stomatitis, and to compare it with other common anticandida medications. Materials and Methods: Three concentrations of Candida albicans (105, 106, 107 CFU/mL) were prepared. Experimental substances were 5% Sodium bicarbonate, Nystatin, Chlorhexidine, and sterile saline (as control). Each of them was added separately to the same amounts of Candida albicans of different concentrations, and sampled at the intervals of 1, 2, 3 and 4 min. Then, the samples were cultured and incubated. The number of formed colonies was counted for each plate. The data were analyzed, using ANOVA and Tukey test. Results: Sodium bicarbonate showed a noticeable anti-candida effect on the concentrations of 105 and 106 CFU/mL, with almost similar anti-candida effect as Nystatin and chlorehexidine(P=0. 29, P=0. 32). Nystatin was the most effective medication on the concentration of 107 CFU/mL of candida (P=0. 03, P=0. 01). Sodium bicarbonate and Chlorhexidine were less effective in this concentration with no statistically significant difference (P=1. 00). Conclusion: Sodium bicarbonate showed a significant anti-candida effect at low and medium concentrations of Candida albicans, but Nystatin was more effective in the higher concentrations.

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APA: Copy

NAJAFI, SHAMSOLMOULOUK, YAZDANI, REZA, SALARI, BEHZAD, Forouhesh Tehrani, Homa, & KHARRAZI FARD, MOHAMMAD JAVAD. (2016). Effect of sodium bicarbonate against Candida albicans in denture stomatitis: An in vitro study. JOURNAL OF DENTAL MEDICINE, 29(2 ), 92-100. SID. https://sid.ir/paper/25437/en

Vancouver: Copy

NAJAFI SHAMSOLMOULOUK, YAZDANI REZA, SALARI BEHZAD, Forouhesh Tehrani Homa, KHARRAZI FARD MOHAMMAD JAVAD. Effect of sodium bicarbonate against Candida albicans in denture stomatitis: An in vitro study. JOURNAL OF DENTAL MEDICINE[Internet]. 2016;29(2 ):92-100. Available from: https://sid.ir/paper/25437/en

IEEE: Copy

SHAMSOLMOULOUK NAJAFI, REZA YAZDANI, BEHZAD SALARI, Homa Forouhesh Tehrani, and MOHAMMAD JAVAD KHARRAZI FARD, “Effect of sodium bicarbonate against Candida albicans in denture stomatitis: An in vitro study,” JOURNAL OF DENTAL MEDICINE, vol. 29, no. 2 , pp. 92–100, 2016, [Online]. Available: https://sid.ir/paper/25437/en

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