DESIGN AND FABRICATION OF A MICROFLUIDIC CHIP FOR IN VITRO OOCYTE MATURATION

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ZARGARI S.; VELADI H.; SADEGHZADEH B.; SHAHABI P.; FROUNCHI J.; PASHAEI ASL M.

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Journal: TABRIZ JOURNAL OF ELECTRICAL ENGINEERING Year:2016 | Volume:46 | Issue:3 (77) Page(s): 211-221

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Title

DESIGN AND FABRICATION OF A MICROFLUIDIC CHIP FOR IN VITRO OOCYTE MATURATION

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Keywords

ASSISTED REPRODUCTIVE TECHNOLOGY (ART)Q2

MICROFLUIDIC TECHNOLOGYQ2

IN VITRO MATURATION (IVM)Q2

OOCYTEQ2

Abstract

In this paper, we designed and fabricated a microfluidic chip for in vitro OOCYTE maturation. All processes have been simulated using COMSOL multiphysics software prior to fabrication of the microchip, to achieve an optimized geometry. Finally, using soft lithography, we will discuss the different stages of optimized manufacturing process for the designed microchip in detail. The fabricated microchip has been implemented using the commercial elastomer, Poly dimethyl siloxane (PDMS) in the micro fabrication laboratory and have been clinically evaluated over mice OOCYTEs in different stages using infertility laboratory facilities and its issues has been identified and resolved. The maturation process has been compared to the standard IVM of OOCYTEs and significant improvement has been observed.

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APA: Copy

ZARGARI, S., VELADI, H., SADEGHZADEH, B., SHAHABI, P., FROUNCHI, J., & PASHAEI ASL, M.. (2016). DESIGN AND FABRICATION OF A MICROFLUIDIC CHIP FOR IN VITRO OOCYTE MATURATION. TABRIZ JOURNAL OF ELECTRICAL ENGINEERING, 46(3 (77)), 211-221. SID. https://sid.ir/paper/256463/en

Vancouver: Copy

ZARGARI S., VELADI H., SADEGHZADEH B., SHAHABI P., FROUNCHI J., PASHAEI ASL M.. DESIGN AND FABRICATION OF A MICROFLUIDIC CHIP FOR IN VITRO OOCYTE MATURATION. TABRIZ JOURNAL OF ELECTRICAL ENGINEERING[Internet]. 2016;46(3 (77)):211-221. Available from: https://sid.ir/paper/256463/en

IEEE: Copy

S. ZARGARI, H. VELADI, B. SADEGHZADEH, P. SHAHABI, J. FROUNCHI, and M. PASHAEI ASL, “DESIGN AND FABRICATION OF A MICROFLUIDIC CHIP FOR IN VITRO OOCYTE MATURATION,” TABRIZ JOURNAL OF ELECTRICAL ENGINEERING, vol. 46, no. 3 (77), pp. 211–221, 2016, [Online]. Available: https://sid.ir/paper/256463/en

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