EFFECT OF CURCUMIN ON HIPPOCAMPAL LEVELS OF BRAIN-DERIVED NEUROTROPHIC FACTOR AND SERUM LEVELS OF INFLAMMATORY CYTOKINES IN RAT MODEL FOR ALZHEIMER’S DISEASE

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SADOUGHI SEYED DAMOON; KHAYATZADEH JINA

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Journal: Neuroscience Journal of Shefaye Khatam Year:2018 | Volume:6 | Issue:1 Page(s): 1-9

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Title

EFFECT OF CURCUMIN ON HIPPOCAMPAL LEVELS OF BRAIN-DERIVED NEUROTROPHIC FACTOR AND SERUM LEVELS OF INFLAMMATORY CYTOKINES IN RAT MODEL FOR ALZHEIMER’S DISEASE

Author(s)

SADOUGHI SEYED DAMOON | KHAYATZADEH JINA | Issue Writer Certificate

Keywords

CURCUMINQ2

RATSQ3

BRAIN-DERIVEDQ2

NEUROTROPHIC FACTORQ2

Abstract

Introduction: Alzheimer’s disease (AD) is a progressive neurodegenerative disease of the central nervous system. Neuronal injury and oxidative stress in AD increases the level of inflammatory cytokines. CURCUMIN has antioxidant and neuroprotective properties. The aim of this study was to determine the effect of CURCUMIN on hippocampal levels of BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) and serum levels of inflammatory cytokines in an experimental model of AD.Materials and Methods: 28 male RATS divided into 4 groups: Control group (30 days, intraperitoneal injection of DMSO), AD control group (30 days, intraperitoneal injection of DMSO, after induction of AD) and two AD treatment groups with application of 50 and 100 mg/kg of CURCUMIN (30 days, intraperitoneal injection of CURCUMIN, after induction of AD). AD was induced by intraperitoneal injection of 8 mg/kg trimethyltin chloride. At the end of the treatment period, the hippocampal levels of BDNF and serum levels of different cytokines (TNF-a, IL-1b and IL-6) were measured by ELISA method.Results: Compared to AD control group, administration of CURCUMIN with dose of 100 mg/kg significantly increased the hippocampal levels of BDNF (P=0.002) and decreased the serum levels of TNF-a, IL-1b and IL-6 (P=0.001).Conclusion: Administration of CURCUMIN may decrease the serum levels of inflammatory cytokines in AD, possibly via enhancement of the hippocampal levels of BDNF. This study suggests the protective effect of CURCUMIN against neuronal damages and oxidative stress in AD.

Cites

THE EFFECT OF GALLIC ACID ON MOTOR LEARNING AND CEREBELLAR LEVEL OF BRAIN DERIVED NEUROTROPHIC FACTOR IN A RAT MODEL OF AUTISM

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APA: Copy

SADOUGHI, SEYED DAMOON, & KHAYATZADEH, JINA. (2018). EFFECT OF CURCUMIN ON HIPPOCAMPAL LEVELS OF BRAIN-DERIVED NEUROTROPHIC FACTOR AND SERUM LEVELS OF INFLAMMATORY CYTOKINES IN RAT MODEL FOR ALZHEIMER’S DISEASE. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 6(1 ), 1-9. SID. https://sid.ir/paper/257990/en

Vancouver: Copy

SADOUGHI SEYED DAMOON, KHAYATZADEH JINA. EFFECT OF CURCUMIN ON HIPPOCAMPAL LEVELS OF BRAIN-DERIVED NEUROTROPHIC FACTOR AND SERUM LEVELS OF INFLAMMATORY CYTOKINES IN RAT MODEL FOR ALZHEIMER’S DISEASE. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM[Internet]. 2018;6(1 ):1-9. Available from: https://sid.ir/paper/257990/en

IEEE: Copy

SEYED DAMOON SADOUGHI, and JINA KHAYATZADEH, “EFFECT OF CURCUMIN ON HIPPOCAMPAL LEVELS OF BRAIN-DERIVED NEUROTROPHIC FACTOR AND SERUM LEVELS OF INFLAMMATORY CYTOKINES IN RAT MODEL FOR ALZHEIMER’S DISEASE,” NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, vol. 6, no. 1 , pp. 1–9, 2018, [Online]. Available: https://sid.ir/paper/257990/en

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