SELADIN-1: A POSSIBLE NEUROPROTECTIVE AGENT IN ALZHEIMER’S DISEASE

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GHASEMI SEDIGHEH; ABDOLAHI SARA; PASAND MOJDEH HODA; BORHANI HAGHIGHI MARYAM

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Journal: Neuroscience Journal of Shefaye Khatam Year:2017 | Volume:5 | Issue:2 Page(s): 88-97

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Title

SELADIN-1: A POSSIBLE NEUROPROTECTIVE AGENT IN ALZHEIMER’S DISEASE

Author(s)

GHASEMI SEDIGHEH | ABDOLAHI SARA | PASAND MOJDEH HODA | BORHANI HAGHIGHI MARYAM | Issue Writer Certificate

Keywords

ALZHEIMER DISEASEQ2

NEUROPROTECTIVE AGENTSQ2

CHOLESTEROLQ2

Abstract

Introduction: Alzheimer’s disease is a progressive brain dysfunction, which damages and destroys neurons and results in memory loss. Selective Alzheimer’s disease indicator-1 (seladin-1) is a gene and protein that is found to be down-regulated in specific areas of the brain affected by Alzheimer’s disease. Seladin-1 has neuroprotective properties and inhibits caspase-3 activity, a key mediator of apoptosis. Seladin-1 is a multi-functional protein and independently of its activity as a caspase-3 inhibitor, it acts as a CHOLESTEROL biosynthetic enzyme.Cholesterol enhances the formation of lipid rafts inhibits the production of β-amyloid in the membrane of neural cell. CHOLESTEROL homeostasis disorder in neural cells may enhance susceptibility of cells to the toxic agents.Conclusion: Studies have shown that the level of seladin-1 increases during brain development to prevent the loss of neuronal precursor cells.Estrogen and thyroid hormones stimulate the expression of seladin-1. It seems that seladin-1 may act as a mediator of these hormones.

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APA: Copy

GHASEMI, SEDIGHEH, ABDOLAHI, SARA, PASAND MOJDEH, HODA, & BORHANI HAGHIGHI, MARYAM. (2017). SELADIN-1: A POSSIBLE NEUROPROTECTIVE AGENT IN ALZHEIMER’S DISEASE. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 5(2), 88-97. SID. https://sid.ir/paper/257999/en

Vancouver: Copy

GHASEMI SEDIGHEH, ABDOLAHI SARA, PASAND MOJDEH HODA, BORHANI HAGHIGHI MARYAM. SELADIN-1: A POSSIBLE NEUROPROTECTIVE AGENT IN ALZHEIMER’S DISEASE. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM[Internet]. 2017;5(2):88-97. Available from: https://sid.ir/paper/257999/en

IEEE: Copy

SEDIGHEH GHASEMI, SARA ABDOLAHI, HODA PASAND MOJDEH, and MARYAM BORHANI HAGHIGHI, “SELADIN-1: A POSSIBLE NEUROPROTECTIVE AGENT IN ALZHEIMER’S DISEASE,” NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, vol. 5, no. 2, pp. 88–97, 2017, [Online]. Available: https://sid.ir/paper/257999/en

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