THE EFFECT OF CALORIC RESTRICTION AND TREADMILL EXERCISE ON RESERPINE-INDUCED CATALEPSY IN A RAT MODEL OF PARKINSON’S DISEASE

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Yazdian Mohammad Reza; Khalaj Azam; KALHOR NASER

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Journal Paper

Paper Information

Journal: Neuroscience Journal of Shefaye Khatam Year:2018 | Volume:6 | Issue:4 Page(s): 45-52

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Title

THE EFFECT OF CALORIC RESTRICTION AND TREADMILL EXERCISE ON RESERPINE-INDUCED CATALEPSY IN A RAT MODEL OF PARKINSON’S DISEASE

Author(s)

Yazdian Mohammad Reza | Khalaj Azam | KALHOR NASER | Issue Writer Certificate

Keywords

CALORIC RESTRICTIONQ2

CATALEPSYQ2

EXERCISEQ2

PARKINSON DISEASEQ2

RATSQ2

Abstract

Introduction: Parkinson’s disease (PD), a degenerative disorder commonly affects the extrapyramidal system, is the second most common neurodegenerative disorder after Alzheimer’s disease. It has been shown that CALORIC RESTRICTION increases life expectancy, decreases the incidence of several age-related diseases, and preserves youth activities in a large scale of laboratory animals. Several studies have revealed that EXERCISE may have neuroprotective effects and increase neurogenesis and angiogenesis. Therefore, the aim of this study was to investigate the effect of CALORIC RESTRICTION diet on reserpine-induced CATALEPSY in a rat model of PD.Materials and Methods: 54 Wistar male RATS were divided into 9 groups (control, EXERCISE, PD, CALORIC RESTRICTION, PD+exercise, CALORIC RESTRICTION+exercise, PD+CALORIC RESTRICTION, CALORIC RESTRICTION+PD II, and PD+exercise+CALORIC RESTRICTION). PD was induced by administration of reserpine (1 mg/kg, i.p). The bar-test was used to measure cataleptic symptoms. All animals in the EXERCISE group were forced to run on a motorized treadmill (24 m/min for 20 min, 5 days/week) for 3weeks. Animals in the CALORIC RESTRICTION groups were under 30% CALORIC RESTRICTION diets.Results: CATALEPSY was significantly lower in the CALORIC RESTRICTION+PD and PD+exercise groups than in the PD group. Furthermore, there was a significant decrease in CATALEPSY was observed in the PD+exercise+CALORIC RESTRICTION group compared to the PD.Conclusion: CALORIC RESTRICTION of 30 percent and treadmill EXERCISE can improve reserpine-induced CATALEPSY in an animal model of PD. In addition, application of CALORIC RESTRICTION before induction of PD may reduce the severity of complications in PD, including CATALEPSY.

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