EXPERIMENTAL MODELS OF RHEUMATOID ARTHRITIS: ACUTE AND CHRONIC PAIN

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KHANIZADEH ALI MOHAMMAD; KARIMZADEH FARIBA

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Journal: Neuroscience Journal of Shefaye Khatam Year:2017 | Volume:5 | Issue:1 Page(s): 98-109

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Information Journal Paper

Title

EXPERIMENTAL MODELS OF RHEUMATOID ARTHRITIS: ACUTE AND CHRONIC PAIN

Author(s)

KHANIZADEH ALI MOHAMMAD | KARIMZADEH FARIBA | Issue Writer Certificate

Keywords

ARTHRITISQ2

RHEUMATOIDQ2

PAINQ3

DISEASEQ3

Abstract

Introduction: RHEUMATOID ARTHRITIS is the most common chronic inflammatory autoimmune DISEASE with unknown etiology and pathophysiology with various symptoms, such as PAIN, hyperalgesia, and edema. Changes in the level of cytokines, such as TNF-a, IL-6 and IL-1b, are among mechanisms which have been suggested to cause chronic inflammation and have a key role in the design of experimental models of RHEUMATOID ARTHRITIS. The main experimental models of RHEUMATOID ARTHRITIS are Carageen, CFA, collagen-induced ARTHRITIS and Zymosan models. In these models, occurrence of thermal hyperalgesia, mechanical allodynia, and PAIN-induced motor impairment have been reported. These models assess the effectiveness of medications and the mechanisms of PAIN relief in RHEUMATOID ARTHRITIS.Conclusion: The use of a valid model of RHEUMATOID ARTHRITIS could help to investigate the pathophysiological mechanisms of PAIN and improve our studies on appropriate treatments for PAIN.

Cites

Influence of rheumatoid arthritis on women's sexual function: A systematic review and meta-analysis

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APA: Copy

KHANIZADEH, ALI MOHAMMAD, & KARIMZADEH, FARIBA. (2017). EXPERIMENTAL MODELS OF RHEUMATOID ARTHRITIS: ACUTE AND CHRONIC PAIN. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 5(1), 98-109. SID. https://sid.ir/paper/258111/en

Vancouver: Copy

KHANIZADEH ALI MOHAMMAD, KARIMZADEH FARIBA. EXPERIMENTAL MODELS OF RHEUMATOID ARTHRITIS: ACUTE AND CHRONIC PAIN. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM[Internet]. 2017;5(1):98-109. Available from: https://sid.ir/paper/258111/en

IEEE: Copy

ALI MOHAMMAD KHANIZADEH, and FARIBA KARIMZADEH, “EXPERIMENTAL MODELS OF RHEUMATOID ARTHRITIS: ACUTE AND CHRONIC PAIN,” NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, vol. 5, no. 1, pp. 98–109, 2017, [Online]. Available: https://sid.ir/paper/258111/en

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