THE NEUROPROTECTIVE ROLE OF PROGESTERONE IN TRAUMATIC BRAIN INJURY; REDUCTION OF INFLAMMATORY CYTOKINES

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SAHAB NEGAH SAJAD; ESHAGHABADI AREZOU; MOHAMMADZADEH ELHAM

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Journal: Neuroscience Journal of Shefaye Khatam Year:2015 | Volume:3 | Issue:4 Page(s): 139-150

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Title

THE NEUROPROTECTIVE ROLE OF PROGESTERONE IN TRAUMATIC BRAIN INJURY; REDUCTION OF INFLAMMATORY CYTOKINES

Author(s)

SAHAB NEGAH SAJAD | ESHAGHABADI AREZOU | MOHAMMADZADEH ELHAM | Issue Writer Certificate

Keywords

BRAIN INJURIESQ2

PROGESTERONEQ3

NEUROPROTECTIVE AGENTSQ3

Abstract

Introduction: Traumatic brain injury (TBI) is one of the leading causes of death of men under the age of 35 that mostly occurs during the road accidents. Current clinical treatments cannot prevent the secondary brain damage induced by cytotoxicity. PROGESTERONE, as a primary sex hormone, is a neuroprotective compound in TBI and stroke. Indeed, PROGESTERONE increases anti-oxidant activities, decreases inflammatory factors, and reduces the expression of inflammatory cytokine, which can prevent secondary brain injury and edema.Conclusion: This review focused on the preventive effect of PROGESTERONE on secondary brain injury and edema by modulation of inflammatory factors in TBI. Although, the exact mechanism of TBI has not been discovered, studies suggest that this hormone can be a safe treatment for TBI and other neurodegenerative diseases.

Cites

THE ROLE OF MICRO-RNAS IN POST-TRAUMATIC STRESS DISORDER

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APA: Copy

SAHAB NEGAH, SAJAD, ESHAGHABADI, AREZOU, & MOHAMMADZADEH, ELHAM. (2015). THE NEUROPROTECTIVE ROLE OF PROGESTERONE IN TRAUMATIC BRAIN INJURY; REDUCTION OF INFLAMMATORY CYTOKINES. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 3(4), 139-150. SID. https://sid.ir/paper/258169/en

Vancouver: Copy

SAHAB NEGAH SAJAD, ESHAGHABADI AREZOU, MOHAMMADZADEH ELHAM. THE NEUROPROTECTIVE ROLE OF PROGESTERONE IN TRAUMATIC BRAIN INJURY; REDUCTION OF INFLAMMATORY CYTOKINES. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM[Internet]. 2015;3(4):139-150. Available from: https://sid.ir/paper/258169/en

IEEE: Copy

SAJAD SAHAB NEGAH, AREZOU ESHAGHABADI, and ELHAM MOHAMMADZADEH, “THE NEUROPROTECTIVE ROLE OF PROGESTERONE IN TRAUMATIC BRAIN INJURY; REDUCTION OF INFLAMMATORY CYTOKINES,” NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, vol. 3, no. 4, pp. 139–150, 2015, [Online]. Available: https://sid.ir/paper/258169/en

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