A STUDY ON THE EFFECT OF SEVEN DIFFERENT COMPOUNDS OF CANNABIS EXTRACT ON THE ACCUMULATION OF AMYLOID PEPTIDE IN ALZHEIMER'S DISEASE THROUGH MOLECULAR SIMULATIONS

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JALALIAN FAEZEH; JEBALI ALI

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Journal: Journal of Health and Biomedical Informatics Year:2017 | Volume:4 | Issue:3 Page(s): 222-231

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Title

A STUDY ON THE EFFECT OF SEVEN DIFFERENT COMPOUNDS OF CANNABIS EXTRACT ON THE ACCUMULATION OF AMYLOID PEPTIDE IN ALZHEIMER'S DISEASE THROUGH MOLECULAR SIMULATIONS

Author(s)

JALALIAN FAEZEH | JEBALI ALI | Issue Writer Certificate

Keywords

AMYLOID PEPTIDEQ2

ALZHEIMER'S DISEASEQ1

CANNABIS EXTRACTQ2

SIMULATIONQ2

MOLECULAR DYNAMICSQ2

Abstract

Introduction: ALZHEIMER'S DISEASE is a progressive cerebrovascular disease with irreversible damage, which gradually degrades the mental abilities of the patient. In this study, AMYLOID PEPTIDE was exposed to seven different compounds in the canaboid extract and then, the structure and thermodynamic parameters were evaluated.Methods: In this study, the three-dimensional structure of beta-AMYLOID PEPTIDE in patients with ALZHEIMER'S DISEASE was prepared from the rcsb database. The main components of canaboid extract were obtained from CHEBI database too. Then, AMYLOID PEPTIDE was subjected to each of the canaboid extract molecules in the MOLECULAR DYNAMICS SIMULATION software, and its structural and thermodynamic characteristics were evaluated over 3000 picoseconds. Results: Comparison of seven different compounds of CANNABIS EXTRACT showed that all CANNABIS EXTRACT compounds were able to change the structure of AMYLOID PEPTIDE. Each compound was able to change the effective surface and volume, and the level of lipophilicty of AMYLOID PEPTIDEs. Conclusion: The ability of these compounds to change the volume and surface is effective in preventing AMYLOID PEPTIDE accumulation. The findings of this study should be investigated in a laboratory scale and then on the human body to detect the efficacy of canaboid extract components exactly.

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APA: Copy

JALALIAN, FAEZEH, & JEBALI, ALI. (2017). A STUDY ON THE EFFECT OF SEVEN DIFFERENT COMPOUNDS OF CANNABIS EXTRACT ON THE ACCUMULATION OF AMYLOID PEPTIDE IN ALZHEIMER'S DISEASE THROUGH MOLECULAR SIMULATIONS. JOURNAL OF HEALTH AND BIOMEDICAL INFORMATICS, 4(3 ), 222-231. SID. https://sid.ir/paper/258898/en

Vancouver: Copy

JALALIAN FAEZEH, JEBALI ALI. A STUDY ON THE EFFECT OF SEVEN DIFFERENT COMPOUNDS OF CANNABIS EXTRACT ON THE ACCUMULATION OF AMYLOID PEPTIDE IN ALZHEIMER'S DISEASE THROUGH MOLECULAR SIMULATIONS. JOURNAL OF HEALTH AND BIOMEDICAL INFORMATICS[Internet]. 2017;4(3 ):222-231. Available from: https://sid.ir/paper/258898/en

IEEE: Copy

FAEZEH JALALIAN, and ALI JEBALI, “A STUDY ON THE EFFECT OF SEVEN DIFFERENT COMPOUNDS OF CANNABIS EXTRACT ON THE ACCUMULATION OF AMYLOID PEPTIDE IN ALZHEIMER'S DISEASE THROUGH MOLECULAR SIMULATIONS,” JOURNAL OF HEALTH AND BIOMEDICAL INFORMATICS, vol. 4, no. 3 , pp. 222–231, 2017, [Online]. Available: https://sid.ir/paper/258898/en

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