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Title

EFFECT OF POLYMYXIN B ON CLINICAL SIGNS, SERUM HAPTOGLOBIN AND GLUCOSE CONCENTRATIONS FOLLOWING EXPERIMENTAL ENDOTOXEMIA IN SHEEP

Pages

  39-48

Abstract

 In order to evaluate the effects of intravenous POLYMYXIN B on CLINICAL SIGNS, serum haptoglobin and GLUCOSE concentrations’ followingexperimental ENDOTOXEMIA in SHEEP the Present study was Performed.20 clinically healthy Iranian fat-tailed SHEEP were randomly divided to 4 equal groups containing Ploymyxin B 6000 and 12000 U/kg, Positive and negative controls. ENDOTOXEMIA was induced by administration of lipopolysaccharide of Escherichia coli serotype O55: B5 at 0.5 μg/kg, intravenously. Blood sampling and clinical evaluation were Performed Prior and 1.5, 3, 4.5, 6, 24 and 48 hours after ENDOTOXEMIA induction. POLYMYXIN B in both treatment groups was intravenously infused along with 2.5 liter of dextrose 5% Plus to sodium chloride 0.45% at 20 ml/kgbw/hour.Positive control group received endotoxin and 2.5 liter intravenous fluids, subsequently, and fluid therapy was only Performed in negative control one. Serum GLUCOSE and HAPTOGLUBIN were assessed and HAPTOGLUBIN in POLYMYXIN B received groups was significantly lower than Positive control one from hour 3 to 48 after ENDOTOXEMIA induction (P<0.05); however, there were no significant differences between POLYMYXIN B groups. Furthermore, POLYMYXIN B was improved the CLINICAL SIGNS (core body temperature, heart and respiratory rates) of endotoxic animals, significantly. Serum GLUCOSE levels were increased following ENDOTOXEMIA induction but there were no significant differences among Positive control and POLYMYXIN B received groups. Based on the significant effects of POLYMYXIN B on improving the CLINICAL SIGNS and decreasing the circulating HAPTOGLUBIN levels, it could be stated that this drug may be considered as an effective modulator on ovine ENDOTOXEMIA.

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    APA: Copy

    KHEIBARI, P., HAJIMOHAMMADI, A., BADIEI, KH., POURJAFAR, M., & CHALMEH, A.. (2017). EFFECT OF POLYMYXIN B ON CLINICAL SIGNS, SERUM HAPTOGLOBIN AND GLUCOSE CONCENTRATIONS FOLLOWING EXPERIMENTAL ENDOTOXEMIA IN SHEEP. IRANIAN JOURNAL OF VETERINARY CLINICAL SCIENCES, 11(1), 39-48. SID. https://sid.ir/paper/260130/en

    Vancouver: Copy

    KHEIBARI P., HAJIMOHAMMADI A., BADIEI KH., POURJAFAR M., CHALMEH A.. EFFECT OF POLYMYXIN B ON CLINICAL SIGNS, SERUM HAPTOGLOBIN AND GLUCOSE CONCENTRATIONS FOLLOWING EXPERIMENTAL ENDOTOXEMIA IN SHEEP. IRANIAN JOURNAL OF VETERINARY CLINICAL SCIENCES[Internet]. 2017;11(1):39-48. Available from: https://sid.ir/paper/260130/en

    IEEE: Copy

    P. KHEIBARI, A. HAJIMOHAMMADI, KH. BADIEI, M. POURJAFAR, and A. CHALMEH, “EFFECT OF POLYMYXIN B ON CLINICAL SIGNS, SERUM HAPTOGLOBIN AND GLUCOSE CONCENTRATIONS FOLLOWING EXPERIMENTAL ENDOTOXEMIA IN SHEEP,” IRANIAN JOURNAL OF VETERINARY CLINICAL SCIENCES, vol. 11, no. 1, pp. 39–48, 2017, [Online]. Available: https://sid.ir/paper/260130/en

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