Synthesis of N-Aryl Amine Derivatives Using Copper Salts Catalysts

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Ghazanfarpour Darjani Magid; Babapour Kooshalshahi Mahboobeh; Mohamad Alikhani Leila

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Paper Information

Journal: Nashrieh Shimi va Mohandesi Shimi Iran Year:2018 | Volume:37 | Issue:3 Page(s): 97-108

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Information Journal Paper

Title

Synthesis of N-Aryl Amine Derivatives Using Copper Salts Catalysts

Author(s)

Ghazanfarpour Darjani Magid | Babapour Kooshalshahi Mahboobeh | Mohamad Alikhani Leila | Issue Writer Certificate

Keywords

Aryl triflateQ1

Unsymmetrical pipirazineQ1

Cross-coupling reactionQ1

Bulky baseQ1

Copper ChlorideQ1

Polyethylene glycol-400Q1

Abstract

Unsymmetrical piperazines are key constituents of many anti-psychotic pharmaceuticals and bioactive compounds. Given that the selective introduction of an aryl and alkyl motif onto the piperazine skeleton is not always straightforward, direct arylation or alkylation of 1, 4-diaza-bicyclo[2. 2. 2]octane would obviate the inefficiencies associated with the preparation of these target valuable molecules. We have utilized alkyl chlorides as the alkyl source, Aryl triflates as the active aryl source, and 1, 4-diaza-bicyclo[2. 2. 2]octane for the synthesis of N-alkyl-N′-arylpiperazines. The optimum conditions are developed using CuCl and t-BuOLi in PEG-400. Substrates bearing electron-deficient as well as electron-rich groups were successfully coupled under the optimum reaction conditions.

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APA: Copy

Ghazanfarpour Darjani, Magid, Babapour Kooshalshahi, Mahboobeh, & Mohamad Alikhani, Leila. (2018). Synthesis of N-Aryl Amine Derivatives Using Copper Salts Catalysts. NASHRIEH SHIMI VA MOHANDESI SHIMI IRAN (PERSIAN), 37(3 ), 97-108. SID. https://sid.ir/paper/26290/en

Vancouver: Copy

Ghazanfarpour Darjani Magid, Babapour Kooshalshahi Mahboobeh, Mohamad Alikhani Leila. Synthesis of N-Aryl Amine Derivatives Using Copper Salts Catalysts. NASHRIEH SHIMI VA MOHANDESI SHIMI IRAN (PERSIAN)[Internet]. 2018;37(3 ):97-108. Available from: https://sid.ir/paper/26290/en

IEEE: Copy

Magid Ghazanfarpour Darjani, Mahboobeh Babapour Kooshalshahi, and Leila Mohamad Alikhani, “Synthesis of N-Aryl Amine Derivatives Using Copper Salts Catalysts,” NASHRIEH SHIMI VA MOHANDESI SHIMI IRAN (PERSIAN), vol. 37, no. 3 , pp. 97–108, 2018, [Online]. Available: https://sid.ir/paper/26290/en

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