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Cites:

Information Journal Paper

Title

OPTIMIZATION OF NEOMYCIN PRODUCTION BY STREPTOMYCES FRADIAE WITH TAGUCHI METHOD

Pages

  13-19

Abstract

 Antibiotic PRODUCTION is a key area in biotechnology. To enhance the productivity and improve the economics, much attention has been paid on the improvement of the factors employed in the antibiotic PRODUCTION. NEOMYCIN is an important aminoglycoside antibiotic used widely in pharmaceutical preparations. In this project, NEOMYCIN PRODUCTION by STREPTOMYCES FRADIAE was studied. Effective factors include: the composition of culture (starch media due to high polysaccharide carbon resource was selected), optimized pH of 7, temperature of 30°C shaking conditions was selected 150 rpm for 72 hr in electrical shaker or 400 rpm with 0.5 VVM air flux for 144 hr in 5 lit fermentor, the optimized PRODUCTION was 3760 mg/lit. Statistic TAGUCHI METHOD was employed to optimize the PRODUCTION conditions. Results show that the media composition (soybean meal; MgSO4.7H2O; and starch) and pH were the most effective factors in PRODUCTION of NEOMYCIN antibiotic.

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  • Cite

    APA: Copy

    VOSOUGHI, M., KAZEMI VEYSARI, A., TEHRANIAN, S., & ZARABI, A.. (2007). OPTIMIZATION OF NEOMYCIN PRODUCTION BY STREPTOMYCES FRADIAE WITH TAGUCHI METHOD. NASHRIEH SHIMI VA MOHANDESI SHIMI IRAN (PERSIAN), 26(2), 13-19. SID. https://sid.ir/paper/26330/en

    Vancouver: Copy

    VOSOUGHI M., KAZEMI VEYSARI A., TEHRANIAN S., ZARABI A.. OPTIMIZATION OF NEOMYCIN PRODUCTION BY STREPTOMYCES FRADIAE WITH TAGUCHI METHOD. NASHRIEH SHIMI VA MOHANDESI SHIMI IRAN (PERSIAN)[Internet]. 2007;26(2):13-19. Available from: https://sid.ir/paper/26330/en

    IEEE: Copy

    M. VOSOUGHI, A. KAZEMI VEYSARI, S. TEHRANIAN, and A. ZARABI, “OPTIMIZATION OF NEOMYCIN PRODUCTION BY STREPTOMYCES FRADIAE WITH TAGUCHI METHOD,” NASHRIEH SHIMI VA MOHANDESI SHIMI IRAN (PERSIAN), vol. 26, no. 2, pp. 13–19, 2007, [Online]. Available: https://sid.ir/paper/26330/en

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