EFFECT OF PAMIDRONATE ON HYPERCALCEMIA, BUN AND CR IN PATIENTS WITH MALIGNANCY

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KEYHANIAN SHAHRBANOU; ZAKERI HAMIDI MARYAM; FOTOKIAN ZAHRA; SARAVI MOHAMMAD MANSOUR; SARAVI SHADI; SARAVI ALI

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Journal: JOURNAL OF NEYSHABUR UNIVERSITY OF MEDICAL SCIENCES Year:2016 | Volume:4 | Issue:1 Page(s): 50-56

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Title

EFFECT OF PAMIDRONATE ON HYPERCALCEMIA, BUN AND CR IN PATIENTS WITH MALIGNANCY

Author(s)

Keywords

PAMIDRONATEQ2

NEOPLASM METASTASESQ1

HYPERCALCEMIAQ2

BLOOD UREA NITROGENQ2

CREATININEQ2

Abstract

Introduction and Aims: Bone metastases have bad potential effects on the individual life period. One of these complications is HYPERCALCEMIA that causedizziness, nausea, constipation and azotemia. PAMIDRONATE reduces skeletal complications in patients with bone metastases. This study evaluated effect of PAMIDRONATE on HYPERCALCEMIA BUN and Cr in cancer patients.Materials and Methods: In this quasi-experimental study, 41 patients with malignancy referring to Ramsar Imam Sajjad hospital were selected by convenience sampling. In this study 90 mg of PAMIDRONATE was injected intravenously monthly for 3 months. Data collection was done through demographic and clinical data questionnaire and blood samples. Data of before and after intervention were compared. Statistical analysis was performed using paired t tests, chi-square, Friedman and Wilcoxon tests with SPSS v.11.5 andP<0.05 was considered as significant.Results: The most common cancer was breast (43.9%) and bone metastasis point in most patients (65.9%) was diffuse. The results of this study indicated that there wassignificant difference between serum Ca (calcium) (P=0.015), BUN (Blood Urea Nitrogen) (P=0.031), ALKP (Alkalin Phosphatase) (P=0.002) before and after treatment, but there was no significant difference between Cr (Creatinine) concentration before and after treatment (P=0.41).Conclusion: PAMIDRONATE is effective in prevention of HYPERCALCEMIA and decrease BUN and Cr. So, it can be used as main and routine treatment.

Cites

Comparison of the effect of alendronate and pamidronate on bone density of patients with osteoporosis

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APA: Copy

KEYHANIAN, SHAHRBANOU, ZAKERI HAMIDI, MARYAM, FOTOKIAN, ZAHRA, SARAVI, MOHAMMAD MANSOUR, SARAVI, SHADI, & SARAVI, ALI. (2016). EFFECT OF PAMIDRONATE ON HYPERCALCEMIA, BUN AND CR IN PATIENTS WITH MALIGNANCY. JOURNAL OF NEYSHABUR UNIVERSITY OF MEDICAL SCIENCES, 4(1 ), 50-56. SID. https://sid.ir/paper/264421/en

Vancouver: Copy

KEYHANIAN SHAHRBANOU, ZAKERI HAMIDI MARYAM, FOTOKIAN ZAHRA, SARAVI MOHAMMAD MANSOUR, SARAVI SHADI, SARAVI ALI. EFFECT OF PAMIDRONATE ON HYPERCALCEMIA, BUN AND CR IN PATIENTS WITH MALIGNANCY. JOURNAL OF NEYSHABUR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;4(1 ):50-56. Available from: https://sid.ir/paper/264421/en

IEEE: Copy

SHAHRBANOU KEYHANIAN, MARYAM ZAKERI HAMIDI, ZAHRA FOTOKIAN, MOHAMMAD MANSOUR SARAVI, SHADI SARAVI, and ALI SARAVI, “EFFECT OF PAMIDRONATE ON HYPERCALCEMIA, BUN AND CR IN PATIENTS WITH MALIGNANCY,” JOURNAL OF NEYSHABUR UNIVERSITY OF MEDICAL SCIENCES, vol. 4, no. 1 , pp. 50–56, 2016, [Online]. Available: https://sid.ir/paper/264421/en

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