HISTOPATHOLOGICAL EVALUATION OF THE ZEBRAFISH (DANIO RERIO) TESTIS FOLLOWING EXPOSURE TO METHYL PARABEN

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HASSANZADEH NASRIN

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Journal Paper

Paper Information

Journal: INTERNATIONAL JOURNAL OF AQUATIC BIOLOGY Year:2017 | Volume:5 | Issue:2 Page(s): 71-78

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Information Journal Paper

Title

HISTOPATHOLOGICAL EVALUATION OF THE ZEBRAFISH (DANIO RERIO) TESTIS FOLLOWING EXPOSURE TO METHYL PARABEN

Author(s)

HASSANZADEH NASRIN | Issue Writer Certificate

Keywords

HISTOPATHOLOGY

PARABENS

REPRODUCTIVE

TOXICITY

Abstract

Methyl paraben (MP) is widely used as a preservative in various products. It frequentlyenters into aquatic environment and renders potential threat to fish. The aim of this study was toevaluate REPRODUCTIVE TOXICITY of MP on zebrafish (Danio rerio) under laboratory conditions. Malezebrafish were exposed to four concentrations of MP (0.001, 0.01, 1, and 10 mg L-1) for 21 days insemi-static condition. Changes in mean length, mean weight, gonadosomatic index (GSI) andhistology of testis were studied. Treatment at 0.001 to 10 mg L-1 MP had no significant effect on thesurvival, mean length and mean weight of fish. But, GSI decreased in a dose dependent manner andthe decrease was significant in the group that received the highest dose. Histological alteration oftestis consisted of general testicular atrophy, multi-nucleated gonocytes (MNGs), impaired germ cell, spermatogonial proliferation, Leydig cell hyperplasia, interstitial fibrosis and apoptosis of Sertolicells. It was concluded that sub-chronic exposures of MP could adversely affect GSI, disrupt thehistology of testis and produce estrogenic and antispermatogenic activity in male zebrafish.

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APA: Copy

HASSANZADEH, NASRIN. (2017). HISTOPATHOLOGICAL EVALUATION OF THE ZEBRAFISH (DANIO RERIO) TESTIS FOLLOWING EXPOSURE TO METHYL PARABEN. INTERNATIONAL JOURNAL OF AQUATIC BIOLOGY, 5(2 ), 71-78. SID. https://sid.ir/paper/265814/en

Vancouver: Copy

HASSANZADEH NASRIN. HISTOPATHOLOGICAL EVALUATION OF THE ZEBRAFISH (DANIO RERIO) TESTIS FOLLOWING EXPOSURE TO METHYL PARABEN. INTERNATIONAL JOURNAL OF AQUATIC BIOLOGY[Internet]. 2017;5(2 ):71-78. Available from: https://sid.ir/paper/265814/en

IEEE: Copy

NASRIN HASSANZADEH, “HISTOPATHOLOGICAL EVALUATION OF THE ZEBRAFISH (DANIO RERIO) TESTIS FOLLOWING EXPOSURE TO METHYL PARABEN,” INTERNATIONAL JOURNAL OF AQUATIC BIOLOGY, vol. 5, no. 2 , pp. 71–78, 2017, [Online]. Available: https://sid.ir/paper/265814/en

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