P53 AND RB GENES EXPRESSION CHANGES IN ESOPHAGEAL SQUAMOUS CELL CARCINOMAIN IRAN

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MIRHASANI MOGHADAM S.J.; DANESHMAND M.A.; AGHAKHANI A.; EDRISSIAN M.O.; ZALI MOHAMMAD REZA

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Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2003 | Volume:7 | Issue:4 Page(s): 340-345

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Title

P53 AND RB GENES EXPRESSION CHANGES IN ESOPHAGEAL SQUAMOUS CELL CARCINOMAIN IRAN

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Keywords

ESOPHAGEAL SQUAMOUS CELL CARCINOMAQ3

IMMUNOHISTOCHEMISTRYQ4

P53Q4

RBQ4

Abstract

Introduction: ESOPHAGEAL SQUAMOUS CELL CARCINOMA is the third most common gastrointestinal malignancy and is ranked among the first ten worldwide. The effect of some genetic mutations especially those involving cell cycle regulation such as P53, and RB genes in development, progression and prognosis of the disease has been shown: We studied expression changes of these genes in our samples. Methods: The paraffin-embedded tissue samples of 135 patients (68 male and 67 female) with documented ESOPHAGEAL SQUAMOUS CELL CARCINOMA were provided. The samples were collected from 22 pathology centers in Tehran during a period of 3 years from 1999 to 2001.Using IMMUNOHISTOCHEMISTRY method (Avidin -Biotin- Peroxidase), they were stained in our laboratory for detection of P53 , and RB proteins. The results were expressed as frequency and odds ratio. Mann-Whitney Test was used to find any association between expression changes of these genes and the degree of tumor differentiation in each sample.Results: The mean p SD age of patients was 57.39Þ10.66 (M/F=1) and the highest frequency (40%) was seen in the sixth decade of life. Sixty (44.4%) and 66(48.9%) patients were positive for P53 and RB respectively. Among those with positive P53, 36(60%) were RB positive while among those with negative P53, 30(40%) were RB positive. Comparing with the P53 negative cases, P53 positive ones showed a higher (2.25 times) risk of being positive for RB gene. We could find no significant difference between P53 gene expression changes and the degree of tumor differentiation in each sample (p>0.5). The results were the same for RB gene (p>0.5).Discussion: Like other parts of the world, the development of mutation in P53 and RB genes appears to have a key role in the carcinopathogenesis of ESOPHAGEAL SQUAMOUS CELL CARCINOMA in Iran. Also a significant association between the frequency of mutations in each of these genes during development of this cancer is likely.

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APA: Copy

MIRHASANI MOGHADAM, S.J., DANESHMAND, M.A., AGHAKHANI, A., EDRISSIAN, M.O., & ZALI, MOHAMMAD REZA. (2003). P53 AND RB GENES EXPRESSION CHANGES IN ESOPHAGEAL SQUAMOUS CELL CARCINOMAIN IRAN. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 7(4), 340-345. SID. https://sid.ir/paper/26664/en

Vancouver: Copy

MIRHASANI MOGHADAM S.J., DANESHMAND M.A., AGHAKHANI A., EDRISSIAN M.O., ZALI MOHAMMAD REZA. P53 AND RB GENES EXPRESSION CHANGES IN ESOPHAGEAL SQUAMOUS CELL CARCINOMAIN IRAN. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2003;7(4):340-345. Available from: https://sid.ir/paper/26664/en

IEEE: Copy

S.J. MIRHASANI MOGHADAM, M.A. DANESHMAND, A. AGHAKHANI, M.O. EDRISSIAN, and MOHAMMAD REZA ZALI, “P53 AND RB GENES EXPRESSION CHANGES IN ESOPHAGEAL SQUAMOUS CELL CARCINOMAIN IRAN,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 7, no. 4, pp. 340–345, 2003, [Online]. Available: https://sid.ir/paper/26664/en

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