THE EFFECT OF DEHYDROEPIANDROSTERONE SULFATE AND INSULIN RESISTANCE ON SERUM LIPIDS IN MEN WITH CORONARY ARTERY DISEASE

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JAFFARY F.; HABIBI A.; JAFFARY A.

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Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2003 | Volume:7 | Issue:Supplement 2 Page(s): 110-114

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Title

THE EFFECT OF DEHYDROEPIANDROSTERONE SULFATE AND INSULIN RESISTANCE ON SERUM LIPIDS IN MEN WITH CORONARY ARTERY DISEASE

Author(s)

JAFFARY F. | HABIBI A. | JAFFARY A. | Issue Writer Certificate

Keywords

INSULIN RESISTANCEQ2

DHEASQ4

CORONARY ARTERY DISEASEQ3

SERUM LIPIDSQ4

LNSULINQ3

GLUCOSEQ3

Abstract

Introduction. Dehydropeiandrosterone sulfate (DHEAS) is the most abundantly produced adrenal hormone, yet its biologic function has not been defined. A possible relation between DHEAS and CORONARY ARTERY DISEASE (CAD) has been suggested in some studies. On the other hand, insulin affects DHEA concentration and itself has a role in atherosclerosis. This study was designed to investigate DHEAS level and INSULIN RESISTANCE and their relation with SERUM LIPIDS in patients with CAD.Methods. Forty men with chest pain (between 45-65 yr) who were supposed for doing angiography, participated in this study. Patients with obesity or a history of diabetes, hypertension or smoking in recent 6 months were excluded from the study. Serum samples were obtained from each patient in the morning after a 12-hour fast. They were sent for immediate FBS and lipid determination and frozen at 20°C for subsequent hormone analysis. FBS to insulin ratio was considered as an index for INSULIN RESISTANCE.Results. After angiography, 22 patients were assigned in CAD group, 10 in control and 8 were excluded from the study because of inaccessible angiographical response. There was no significant difference in DHEAS, insulin, FBS, lipid levels and FBS/insulin ratio between CAD patients and control group.A statistically significant positive relation between both insulin and DHEAS and LDL and total cholesterol was observed in this study. A strong advantage of our study is both - "clinical" and "angiographically" confirmation of CAD in case group.Discussion. Our findings does not support a protective role of DHEA in development of atherosclerosis. Its role as a missing link between INSULIN RESISTANCE and atherosclerosis has been questioned and its answer merits further investigation.These results also suggest continued skepticism about DHEA role in the etiology or prevention of coronary disease.

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APA: Copy

JAFFARY, F., HABIBI, A., & JAFFARY, A.. (2003). THE EFFECT OF DEHYDROEPIANDROSTERONE SULFATE AND INSULIN RESISTANCE ON SERUM LIPIDS IN MEN WITH CORONARY ARTERY DISEASE. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 7(Supplement 2), 110-114. SID. https://sid.ir/paper/26680/en

Vancouver: Copy

JAFFARY F., HABIBI A., JAFFARY A.. THE EFFECT OF DEHYDROEPIANDROSTERONE SULFATE AND INSULIN RESISTANCE ON SERUM LIPIDS IN MEN WITH CORONARY ARTERY DISEASE. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2003;7(Supplement 2):110-114. Available from: https://sid.ir/paper/26680/en

IEEE: Copy

F. JAFFARY, A. HABIBI, and A. JAFFARY, “THE EFFECT OF DEHYDROEPIANDROSTERONE SULFATE AND INSULIN RESISTANCE ON SERUM LIPIDS IN MEN WITH CORONARY ARTERY DISEASE,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 7, no. Supplement 2, pp. 110–114, 2003, [Online]. Available: https://sid.ir/paper/26680/en

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