EFFECT OF POLYMORPHISM ON PHENOBARBITAL TABLET CHARACTERISTICS

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GHARAVI SEYED MANOUCHEHR; HOOSHFAR GH.A.; TAVAKOLI N.

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Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2000 | Volume:5 | Issue:Supplement 2 Page(s): 41-47

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Title

EFFECT OF POLYMORPHISM ON PHENOBARBITAL TABLET CHARACTERISTICS

Author(s)

GHARAVI SEYED MANOUCHEHR | HOOSHFAR GH.A. | TAVAKOLI N. | Issue Writer Certificate

Keywords

PHENOBARBITALQ4

POLYMORPHISMQ2

DISSOLUTION RATEQ4

Abstract

Background. PHENOBARBITAL consists of different polymorphic forms such as (I), (II) and (III) forms. Every polymorph has certain shape and habit, that may change it's physical characteristics. The physical attributes must be considered for the formulation and manufacturing processes.Methods. In this study a PHENOBARBITAL tablet made by pharmaceutics department laboratory of Isfahan faculty of pharmacy (coded U) were compared with four commercial products made by three Iranian companies (Coded A, D, P) and an American company (coded L). Various tests such as: disintegration time, hardness, weight variation, DISSOLUTION RATE and content uniformity were carried out.Results. Obtained results were in order of: P>L>U>A>D for disintegration time; A>U>D>L>P for hardness; D>U>L>A>P for weigth variation; D>L>U>A>P for dissolution. Melting point of three polymorphic forms of PHENOBARBITAL powder were in order of I>II>III.Discussion. Content uniformity were in acceptable range for all samples. In addition, samples A. D and P were consisted of Polymorphs (I) and (II). Sample U, however, was consisted of pohymorph (II).

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APA: Copy

GHARAVI, SEYED MANOUCHEHR, HOOSHFAR, GH.A., & TAVAKOLI, N.. (2000). EFFECT OF POLYMORPHISM ON PHENOBARBITAL TABLET CHARACTERISTICS. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 5(Supplement 2), 41-47. SID. https://sid.ir/paper/26743/en

Vancouver: Copy

GHARAVI SEYED MANOUCHEHR, HOOSHFAR GH.A., TAVAKOLI N.. EFFECT OF POLYMORPHISM ON PHENOBARBITAL TABLET CHARACTERISTICS. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2000;5(Supplement 2):41-47. Available from: https://sid.ir/paper/26743/en

IEEE: Copy

SEYED MANOUCHEHR GHARAVI, GH.A. HOOSHFAR, and N. TAVAKOLI, “EFFECT OF POLYMORPHISM ON PHENOBARBITAL TABLET CHARACTERISTICS,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 5, no. Supplement 2, pp. 41–47, 2000, [Online]. Available: https://sid.ir/paper/26743/en

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