EFFECT OF EDTA ON GASTRIC MUCOSAL LESION INDUCED BY ASPIRIN

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FESHARAKI MEHRAFARIN; SHARAITI KAMALABADI A.; MOKHTARI R.

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Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2002 | Volume:7 | Issue:2 Page(s): 170-174

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Title

EFFECT OF EDTA ON GASTRIC MUCOSAL LESION INDUCED BY ASPIRIN

Author(s)

FESHARAKI MEHRAFARIN | SHARAITI KAMALABADI A. | MOKHTARI R. | Issue Writer Certificate

Keywords

ASPIRINQ3

EDTAQ4

GASTRIC MUCOSAL LESIONQ4

Abstract

Introduction. Gastric ulcer is a multifactorial disease, which its pathophysioligy has not been clear yet. The aim of this study was to obtain the prophylactic effects of EDTA on ASPIRIN induced GASTRIC MUCOSAL LESIONs.Methods. In fasted male rats the effect of a single oral dose of the EDTA was evaluated in the following test systems: combination of 1 ml EDTA 1.5% + 300 mg/kg ASPIRIN and 1 ml EDTA 1.5%, 2.5%, 5% and 7.5% 30 minutes before 300 mg/kg ASPIRIN. Then the GASTRIC MUCOSAL LESIONs were assessed microscopically and marcroscopically.Results. EDTA at different doses reduced macroscopic and microscpic GASTRIC MUCOSAL LESION induced by ASPIRIN.Discussion. Combination therapy of EDTA and ASPIRIN has distinct advantages regard to both low gastrointestinal toxicity and restored therapeutic activity.

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APA: Copy

FESHARAKI, MEHRAFARIN, SHARAITI KAMALABADI, A., & MOKHTARI, R.. (2002). EFFECT OF EDTA ON GASTRIC MUCOSAL LESION INDUCED BY ASPIRIN. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 7(2), 170-174. SID. https://sid.ir/paper/26770/en

Vancouver: Copy

FESHARAKI MEHRAFARIN, SHARAITI KAMALABADI A., MOKHTARI R.. EFFECT OF EDTA ON GASTRIC MUCOSAL LESION INDUCED BY ASPIRIN. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2002;7(2):170-174. Available from: https://sid.ir/paper/26770/en

IEEE: Copy

MEHRAFARIN FESHARAKI, A. SHARAITI KAMALABADI, and R. MOKHTARI, “EFFECT OF EDTA ON GASTRIC MUCOSAL LESION INDUCED BY ASPIRIN,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 7, no. 2, pp. 170–174, 2002, [Online]. Available: https://sid.ir/paper/26770/en

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