TREATMENT OF CUTANEOUS LEISHMANIASIS WITH KETOCONAZOLE CREAM

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MOUMENI A.; AMIN JAVAHERI M.A.S.; OMIDGHAEMI M.R.

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Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2001 | Volume:6 | Issue:1 Page(s): 24-26

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Title

TREATMENT OF CUTANEOUS LEISHMANIASIS WITH KETOCONAZOLE CREAM

Author(s)

MOUMENI A. | AMIN JAVAHERI M.A.S. | OMIDGHAEMI M.R. | Issue Writer Certificate

Keywords

KETOKONAZOLEQ2

TOPICAL CREAMQ4

LEISHMANIASISQ4

CLINICAL TRIALQ4

Abstract

Introduction: Cutaneous LEISHMANIASIS (CL) is endemic in many countries. It has been recognized as a major public health problem in Iran. Many drugs have been suggested for treatment of CL but non of them proved to be effective. Recently ketoconazole has been used to treat CL patients and it has been reported that was effective. To compare the efficacy of ketoconazole cream with placebo in the treatment of CL. Methods: In a double-blind placebo-controlled study, patients with proven CL was treated with ketoconazole cream or placebo cream. The duration of the treatment was 21 days and the patients were visited on the days 7, 14 and 21. The patients were followed for one month after the end of treatment. Results: The study was complete in 73 patients (45 male, 28 female). The mean age of the patients was 19.9 years. 38 patients received ketoconazole and 35 patients were treated with placebo cream. At the end of treatment (day 21), complete healing occurred in 15.7 % of the ketoconazole group in comparison with 14.3% of the patients who were treated with placebo cream. One month of the end of treatment the lesions in 28.9% of ketoconazole group and 22.8% of placebo group were healed. Discussion: Although ketoconazole tablet has been reported to be effective in treatment of C but the low response rete in patients receiving ketoconazole cream indicate that it cannot be used as the single agent in treatment of CL patients.

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APA: Copy

MOUMENI, A., AMIN JAVAHERI, M.A.S., & OMIDGHAEMI, M.R.. (2001). TREATMENT OF CUTANEOUS LEISHMANIASIS WITH KETOCONAZOLE CREAM. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 6(1), 24-26. SID. https://sid.ir/paper/26784/en

Vancouver: Copy

MOUMENI A., AMIN JAVAHERI M.A.S., OMIDGHAEMI M.R.. TREATMENT OF CUTANEOUS LEISHMANIASIS WITH KETOCONAZOLE CREAM. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2001;6(1):24-26. Available from: https://sid.ir/paper/26784/en

IEEE: Copy

A. MOUMENI, M.A.S. AMIN JAVAHERI, and M.R. OMIDGHAEMI, “TREATMENT OF CUTANEOUS LEISHMANIASIS WITH KETOCONAZOLE CREAM,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 6, no. 1, pp. 24–26, 2001, [Online]. Available: https://sid.ir/paper/26784/en

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