Computational Simulation of Mechanical stimulation of Mesenchymal Stem Cells under Uniaxial Cyclic Tensile Stress

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VAHIDI B.; Mirakhorli F.; HAGHIGHIPOUR N.; Esmaeli P.

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Paper Information

Journal: JOURNAL OF MECHANICAL ENGINEERING Year:2021 | Volume:50 | Issue:4 (93) Page(s): 219-227

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Title

Computational Simulation of Mechanical stimulation of Mesenchymal Stem Cells under Uniaxial Cyclic Tensile Stress

Author(s)

VAHIDI B. | Mirakhorli F. | HAGHIGHIPOUR N. | Esmaeli P. | Issue Writer Certificate

Keywords

Mesenchymal stem cell

Uniaxial cyclic strain

Cell morphology

Lying angle

Abstract

To respond to the external forces, adherent cells are reoriented from random orientation to an ordered and homogeneous one, regarding the applied strain direction. Furthermore, in subcellular scale, cytoskeleton and stress filaments with polarization generate inner contractile forces leading to a reorientation of the cell at a specific angle. In the present study, morphological changes of Mesenchymal stem cells under cyclic strain toward myogenic differentiation were analyzed. Simulation of stem cell morphological changes using a nonlinear mechanical model (viscoelastic) is the innovative aspect of this research. To do so, Mesenchymal stem cells with real size by the use of finite element method were designed in the Comsol software. Furthermore, time-dependent mechanical properties were applied. The Uniaxial cyclic strain is applied to the substrate, and the frequency of the strain was considered as one of the variables. The Lying angle of the cell on the substrate was varied from 34 to 90° . Also, Young’ s modulus of the substrate and the role of strain alteration were investigated. The results revealed that the stress distribution on the cell and the nucleus are strongly dependent on the Lying angle. The approximate angle in which the stress and strain is minimum was calculated about 70 degrees.

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APA: Copy

VAHIDI, B., Mirakhorli, F., HAGHIGHIPOUR, N., & Esmaeli, P.. (2021). Computational Simulation of Mechanical stimulation of Mesenchymal Stem Cells under Uniaxial Cyclic Tensile Stress. JOURNAL OF MECHANICAL ENGINEERING, 50(4 (93) ), 219-227. SID. https://sid.ir/paper/269789/en

Vancouver: Copy

VAHIDI B., Mirakhorli F., HAGHIGHIPOUR N., Esmaeli P.. Computational Simulation of Mechanical stimulation of Mesenchymal Stem Cells under Uniaxial Cyclic Tensile Stress. JOURNAL OF MECHANICAL ENGINEERING[Internet]. 2021;50(4 (93) ):219-227. Available from: https://sid.ir/paper/269789/en

IEEE: Copy

B. VAHIDI, F. Mirakhorli, N. HAGHIGHIPOUR, and P. Esmaeli, “Computational Simulation of Mechanical stimulation of Mesenchymal Stem Cells under Uniaxial Cyclic Tensile Stress,” JOURNAL OF MECHANICAL ENGINEERING, vol. 50, no. 4 (93) , pp. 219–227, 2021, [Online]. Available: https://sid.ir/paper/269789/en

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