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Information Journal Paper

Title

UROLOGICAL ONCOLOGY: Long-Term Renal Function Outcomes in Bladder Cancer After Radical Cystectomy

Pages

  784-789

Abstract

  PURPOSE: To evaluate postoperative renal function and risk factors for the loss of renal function in patients who had undergone radical cystectomy. MATERIALS AND METHODS: A retrospective single institutional study evaluated 70 patients, including 54 men and 16 women who underwent radical cystectomy. The median follow-up period was 34. 5 months (range, 12 to 228 months). In this cohort, four types of urinary diversions were studied, including ileal neobladder (n = 24), ileocecal neobladder (n = 12), ileal conduit (n = 25), and cutaneous ureterostomy (n = 9). Postoperative changes in renal function were reviewed, and the estimated serum creatinine-based glomerular filtration rate (eGFR) was calculated. The variables analyzed were age, a prior history of hypertension or diabetes mellitus, pre-operative renal function, type of urinary diversion, the postoperative occurrence of acute pyelonephritis, and the presence of chemotherapy. RESULTS: The mean eGFR was 74. 6 (range, 15. 2 to 155. 1) mL/min/1. 73 m2 before surgery and 63. 6 (range, 8. 7 to 111. 5) mL/min/1. 73 m2 at the last follow-up. The 10-year renal deterioration-free interval was 63. 8%. Multivariate analysis showed that a postoperative episode of acute pyelonephritis [Odds Ratio (OR), 3. 21; 95% Confidence Interval (CI), 1. 14 to 9. 02; P =. 03] and the presence of chemotherapy (OR, 3. 27; 95% CI, 1. 33 to 8. 01; P =. 01) were significant adverse factors. CONCLUSION: Twenty-four (34. 2%) patients demonstrated reduced renal function during the follow-up period. Postoperative episodes of acute pyelonephritis and the presence of chemotherapy were found to be significant adverse factors.

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    • Cite

    APA: Copy

    Osawa, Takahiro, Shinohara, Nobuo, Maruyama, Satoru, Oba, Koji, Abe, Takashige, Maru, Shintaro, Takada, Norikata, Sazawa, Ataru, & Nonomura, Katsuya. (2013). UROLOGICAL ONCOLOGY: Long-Term Renal Function Outcomes in Bladder Cancer After Radical Cystectomy. UROLOGY JOURNAL, 10(1), 784-789. SID. https://sid.ir/paper/271089/en

    Vancouver: Copy

    Osawa Takahiro, Shinohara Nobuo, Maruyama Satoru, Oba Koji, Abe Takashige, Maru Shintaro, Takada Norikata, Sazawa Ataru, Nonomura Katsuya. UROLOGICAL ONCOLOGY: Long-Term Renal Function Outcomes in Bladder Cancer After Radical Cystectomy. UROLOGY JOURNAL[Internet]. 2013;10(1):784-789. Available from: https://sid.ir/paper/271089/en

    IEEE: Copy

    Takahiro Osawa, Nobuo Shinohara, Satoru Maruyama, Koji Oba, Takashige Abe, Shintaro Maru, Norikata Takada, Ataru Sazawa, and Katsuya Nonomura, “UROLOGICAL ONCOLOGY: Long-Term Renal Function Outcomes in Bladder Cancer After Radical Cystectomy,” UROLOGY JOURNAL, vol. 10, no. 1, pp. 784–789, 2013, [Online]. Available: https://sid.ir/paper/271089/en

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