PYRIMETHAMINE AND PROGUANIL RESISTANCE-CONFERRING KEY MUTATIONS IN DIHYDROFOLATE REDUCTASE GENE OF PLASMODIUM FALCIPARUM ISOLATES FROM IRAN

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MASOUD A.; KESHAVARZ H.; MAHBOUDI F.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Iranian Journal of Public Health Year:2003 | Volume:32 | Issue:4 Page(s): 8-12

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Title

PYRIMETHAMINE AND PROGUANIL RESISTANCE-CONFERRING KEY MUTATIONS IN DIHYDROFOLATE REDUCTASE GENE OF PLASMODIUM FALCIPARUM ISOLATES FROM IRAN

Author(s)

MASOUD A. | KESHAVARZ H. | MAHBOUDI F. | Issue Writer Certificate

Keywords

PLASMODIUM FALCIPARUM

DRUG RESISTANCE

PYRIMETHAMINE

PROGUANIL

IRAN

Abstract

Using mutation specific PCR assay and analysis of position 108 amino acid in dihydrofolate reductase-thymidilate synthase gene in 70 PLASMODIUM FALCIPARUM isolates of malarial patients from southern areas of IRAN, showed 4 different situations: i- wild type (108-Ser) ii-mutant type (108-Thr) iii-mutant type (108-Asn) and iv-mixed wild and mutant type (108-Ser+Thr) with frequency of 58(82.8%), 2(2.9%), 8(11.4%) and 2(2.9%) respectively. Many studies have demonstrated that mutations in position 108 have key role for emerging resistance to anti-folate drugs in falciparum malaria so, the resistance to PYRIMETHAMINE and PROGUANIL, presents in PLASMODIUM FALCIPARUM isolates from malarious endemic regions of IRAN.

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APA: Copy

MASOUD, A., KESHAVARZ, H., & MAHBOUDI, F.. (2003). PYRIMETHAMINE AND PROGUANIL RESISTANCE-CONFERRING KEY MUTATIONS IN DIHYDROFOLATE REDUCTASE GENE OF PLASMODIUM FALCIPARUM ISOLATES FROM IRAN. IRANIAN JOURNAL OF PUBLIC HEALTH, 32(4), 8-12. SID. https://sid.ir/paper/271983/en

Vancouver: Copy

MASOUD A., KESHAVARZ H., MAHBOUDI F.. PYRIMETHAMINE AND PROGUANIL RESISTANCE-CONFERRING KEY MUTATIONS IN DIHYDROFOLATE REDUCTASE GENE OF PLASMODIUM FALCIPARUM ISOLATES FROM IRAN. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2003;32(4):8-12. Available from: https://sid.ir/paper/271983/en

IEEE: Copy

A. MASOUD, H. KESHAVARZ, and F. MAHBOUDI, “PYRIMETHAMINE AND PROGUANIL RESISTANCE-CONFERRING KEY MUTATIONS IN DIHYDROFOLATE REDUCTASE GENE OF PLASMODIUM FALCIPARUM ISOLATES FROM IRAN,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 32, no. 4, pp. 8–12, 2003, [Online]. Available: https://sid.ir/paper/271983/en

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