EFFECT OF VITAMINS A, E, C AND OMEGA-3 FATTY ACIDS ON LIPID PEROXIDATION IN STREPTOZOTOCIN INDUCED DIABETIC RATS

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FAKHER SH.; JALALI M.; TABEI S.M.B.; ZERAATI H.A.; JAVADI E.; SADEGHI M.R.; MOSTAFAVI E.; FATEHI F.

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Journal: Iranian Journal of Public Health Year:2007 | Volume:36 | Issue:2 Page(s): 58-63

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Title

EFFECT OF VITAMINS A, E, C AND OMEGA-3 FATTY ACIDS ON LIPID PEROXIDATION IN STREPTOZOTOCIN INDUCED DIABETIC RATS

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Keywords

VITAMIN C

VITAMIN E

VITAMIN A

OMEGA3 FATTY ACID

MALONDIALDEHYDE

Abstract

Background: To assess the effect of supplementation with vitamins A, E and C and w-3 fatty acids on lipid peroxidation in streptozotocin (STZ) induced diabetic rats.Methods: Sixty four male wistar rats weighting 250g were divided into four groups as normal control, diabetic control, diabetic with VITAMIN A, E as well as C supplementation and diabetic with w-3 fatty acids supplementation. After four weeks of treatment the rats were anesthetized and MALONDIALDEHYDE (MDA) levels were investigated in blood samples, liver and heart homogenate.Results: In diabetic 3.0rats MDA level in plasma, liver and heart was significantly more elevated than normal control rats (P<0.05). VITAMIN A, E and C supplementation caused significant decrease in plasma, liver and heart MDA (P<0.05). A significant decrease in heart MDA (P< 0.05) was observed in diabetic rats with w-3 fatty acids supplementation. Conclusion: Supplementation of VITAMIN A, E and C and w-3 fatty acids was found to decrease lipid peroxidation to some extent in diabetic rats and they can be valuable candidates in the treatment of the complications of diabetes.

Cites

EFFECTS OF OMEGA-3 FATTY ACIDS SUPPLEMENT ON ANTIOXIDANT ENZYMES ACTIVITY IN TYPE 2 DIABETIC PATIENTS

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APA: Copy

FAKHER, SH., JALALI, M., TABEI, S.M.B., ZERAATI, H.A., JAVADI, E., SADEGHI, M.R., MOSTAFAVI, E., & FATEHI, F.. (2007). EFFECT OF VITAMINS A, E, C AND OMEGA-3 FATTY ACIDS ON LIPID PEROXIDATION IN STREPTOZOTOCIN INDUCED DIABETIC RATS. IRANIAN JOURNAL OF PUBLIC HEALTH, 36(2), 58-63. SID. https://sid.ir/paper/272422/en

Vancouver: Copy

FAKHER SH., JALALI M., TABEI S.M.B., ZERAATI H.A., JAVADI E., SADEGHI M.R., MOSTAFAVI E., FATEHI F.. EFFECT OF VITAMINS A, E, C AND OMEGA-3 FATTY ACIDS ON LIPID PEROXIDATION IN STREPTOZOTOCIN INDUCED DIABETIC RATS. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2007;36(2):58-63. Available from: https://sid.ir/paper/272422/en

IEEE: Copy

SH. FAKHER, M. JALALI, S.M.B. TABEI, H.A. ZERAATI, E. JAVADI, M.R. SADEGHI, E. MOSTAFAVI, and F. FATEHI, “EFFECT OF VITAMINS A, E, C AND OMEGA-3 FATTY ACIDS ON LIPID PEROXIDATION IN STREPTOZOTOCIN INDUCED DIABETIC RATS,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 36, no. 2, pp. 58–63, 2007, [Online]. Available: https://sid.ir/paper/272422/en

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