EVALUATION OF EFFECTIVENESS OF ETHANOLIC EXTRACT OF ARTEMISIA AUCHERI, INDIVIDUALLY AND IN COMBINATION WITH CHLOROQUINE, ON CHLOROQUINE - SENSITIVE STRAIN OF PLASMODIUM BERGHEI IN SOURIAN MICE

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KHODADADI MASOMEH; NATEGHPOUR MEHDI; SOURI EFFAT; FARIVAR LEILA; MOTEVALLI HAGHI AFSANE; RAHIMI FROUSHANI ABBAS; KARBALAEI ZEINAB

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Journal: Iranian Journal of Public Health Year:2013 | Volume:42 | Issue:8 Page(s): 883-888

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Title

EVALUATION OF EFFECTIVENESS OF ETHANOLIC EXTRACT OF ARTEMISIA AUCHERI, INDIVIDUALLY AND IN COMBINATION WITH CHLOROQUINE, ON CHLOROQUINE - SENSITIVE STRAIN OF PLASMODIUM BERGHEI IN SOURIAN MICE

Author(s)

Keywords

ARTEMISIA AUCHERI

PLASMODIUM BERGHEI

COMBINATION THERAPY

CHLOROQUINE

Abstract

Background: Drug resistance in malaria parasites is extending in the world particularly in chemical synthesized drugs such as 4- aminoquinolines and aminoalcoholes. Employing herbal extracts is encouraged by WHO in the malarious areas. In this study, the effectiveness of ethanolic extract of ARTEMISIA AUCHERI individually and in combination with CHLOROQUINE, has been considered against CHLOROQUINE - sensitive strain of PLASMODIUM BERGHEI.Methods: At the first stage, ED50 of A. aucheri and CHLOROQUINE on P. berghei was calculated using in vivo test. Then based on the ED50s combination of A. aucheri and CHLOROQUINE with ratios of 0/100, 10/90, 20/80, 30/70, 40/60, 50 /50, 60/40, 70/30, 80/20, 90/10 and100/0 were tested against the parasite. For evaluating the adverse effect of A. aucheri on the mice, for two weeks 1000mg/kg of the extract was daily employed and the mice were followed up for fifty days Results: ED50s for CHLOROQUINE and A. aucheri were 1.6mg/kg and 1000mg/kg respectively. The outcome of two drugs combination on the mice showed antagonistic effects on the CHLOROQUINE - sensitive strain of parasite. Two weeks daily administration of A. aucheri had no toxic effect on the mice.Conclusion: A. aucheri individually can be effective in reducing the parasite while in combination with CHLOROQUINE loses its property.

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APA: Copy

KHODADADI, MASOMEH, NATEGHPOUR, MEHDI, SOURI, EFFAT, FARIVAR, LEILA, MOTEVALLI HAGHI, AFSANE, RAHIMI FROUSHANI, ABBAS, & KARBALAEI, ZEINAB. (2013). EVALUATION OF EFFECTIVENESS OF ETHANOLIC EXTRACT OF ARTEMISIA AUCHERI, INDIVIDUALLY AND IN COMBINATION WITH CHLOROQUINE, ON CHLOROQUINE - SENSITIVE STRAIN OF PLASMODIUM BERGHEI IN SOURIAN MICE. IRANIAN JOURNAL OF PUBLIC HEALTH, 42(8), 883-888. SID. https://sid.ir/paper/273061/en

Vancouver: Copy

KHODADADI MASOMEH, NATEGHPOUR MEHDI, SOURI EFFAT, FARIVAR LEILA, MOTEVALLI HAGHI AFSANE, RAHIMI FROUSHANI ABBAS, KARBALAEI ZEINAB. EVALUATION OF EFFECTIVENESS OF ETHANOLIC EXTRACT OF ARTEMISIA AUCHERI, INDIVIDUALLY AND IN COMBINATION WITH CHLOROQUINE, ON CHLOROQUINE - SENSITIVE STRAIN OF PLASMODIUM BERGHEI IN SOURIAN MICE. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2013;42(8):883-888. Available from: https://sid.ir/paper/273061/en

IEEE: Copy

MASOMEH KHODADADI, MEHDI NATEGHPOUR, EFFAT SOURI, LEILA FARIVAR, AFSANE MOTEVALLI HAGHI, ABBAS RAHIMI FROUSHANI, and ZEINAB KARBALAEI, “EVALUATION OF EFFECTIVENESS OF ETHANOLIC EXTRACT OF ARTEMISIA AUCHERI, INDIVIDUALLY AND IN COMBINATION WITH CHLOROQUINE, ON CHLOROQUINE - SENSITIVE STRAIN OF PLASMODIUM BERGHEI IN SOURIAN MICE,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 42, no. 8, pp. 883–888, 2013, [Online]. Available: https://sid.ir/paper/273061/en

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