EFFECT OF GABA ON PLASMA CYTOKINE CONCENTRATION AND BETA AND ALPHA CELL MASS IN CD1 DIABETIC MICE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SOLTANI N.; KESHAVARZ MANSOUR; WANG CH.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM) Year:2008 | Volume:10 | Issue:4 (SN 40) Page(s): 401-408

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

1,191

Download:

Cites:

Information Journal Paper

Title

EFFECT OF GABA ON PLASMA CYTOKINE CONCENTRATION AND BETA AND ALPHA CELL MASS IN CD1 DIABETIC MICE

Author(s)

SOLTANI N. | KESHAVARZ MANSOUR | WANG CH. | Issue Writer Certificate

Keywords

INSULINQ3

GLUCAGONQ3

GABAQ3

TYPE I DIABETESQ3

BETA CELL AND ALPHA CELL MASSQ3

CYTOKINESQ3

Abstract

Introduction: TYPE I DIABETES is an autoimmune disease associated with T lymphocytes function in beta cells. This process can increase cytokine secretion, which can cause beta cell inflammation and death. Since GABA, (γ-aminobutyric acid) is a major inhibitory neurotransmitter, and low concentration of GABA can increase cytokine secretion, the aim of this study was demonstrate to the inhibitory effect of GABA administration on cytokine secretion and decrease in beta cell death and also to show the ability of beta cells in INSULIN secretion. Material and Methods: Seven week old CD1 mice were used. To induce diabetes, animals received 40 mg/kg of STZ five days continuously. Two months later, animals were divided into two groups, one receiving 200 micromole of GABA and the other (controls) the same volume of PBS for 10 weeks. Results: Serum GLUCAGON levels, and alpha cells significantly decreased in the (IL12 IL1β, TNFa) mass and some cytokine levels in the GABA group. Plasma INSULIN level and beta cell mass significantly increased in comparison to the control group. Conclusion: From the results of this study we conclude that GABA administration causes inhibition in cytokine secretion, improves beta cell mass and increases INSULIN secretion. May be, in the future, if GABA shows no side effects we can use GABA for type one diabetes.

Cites

No record.

References

No record.

Cite

APA: Copy

SOLTANI, N., KESHAVARZ, MANSOUR, & WANG, CH.. (2008). EFFECT OF GABA ON PLASMA CYTOKINE CONCENTRATION AND BETA AND ALPHA CELL MASS IN CD1 DIABETIC MICE. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 10(4 (SN 40)), 401-408. SID. https://sid.ir/paper/27403/en

Vancouver: Copy

SOLTANI N., KESHAVARZ MANSOUR, WANG CH.. EFFECT OF GABA ON PLASMA CYTOKINE CONCENTRATION AND BETA AND ALPHA CELL MASS IN CD1 DIABETIC MICE. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2008;10(4 (SN 40)):401-408. Available from: https://sid.ir/paper/27403/en

IEEE: Copy

N. SOLTANI, MANSOUR KESHAVARZ, and CH. WANG, “EFFECT OF GABA ON PLASMA CYTOKINE CONCENTRATION AND BETA AND ALPHA CELL MASS IN CD1 DIABETIC MICE,” IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 10, no. 4 (SN 40), pp. 401–408, 2008, [Online]. Available: https://sid.ir/paper/27403/en

Related Journal Papers