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Information Journal Paper

Title

HAPLOTYPE ANALYSIS OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR γ GENE POLYMORPHISMS AND THE LIPOPROTEIN (A) LEVEL

Pages

  973-979

Abstract

 Background: Lipoprotein (a) [Lp(a)], as an independent risk factor for cardiovascular disease, is more likely to be genetically determined according to the increasing evidence of epidemiologic and clinical studies in recent years. Peroxisome proliferator-activated receptor (PPAR)γ , the ligand-activated transcription factors, was con-sidered as an indispensable role in the process of lipid metabolism. This study was designed to explore the as-sociations of three single-nucleotide POLYMORPHISMs (SNPs) and the HAPLOTYPEs of the peroxisome proliferator-activated receptor (PPAR)γ gene with the level of Lp(a). Methods: Participants were recruited under the framework of the PMMJS (The Prevention of Metabolic Syn-drome (MS) and Multi-metabolic Disorders in Jiangsu Province of China Study) from Apr 1999 to Jun 2004. Overall, 644 subjects were randomly selected and 3 SNPs of PPARγ gene (rs10865710, rs1805192, rs4684847) were genotyped. Results: After adjusting for age, sex, cigarette smoking, alcohol drinking, waist circumference and body mass index, rs4684847 was significantly associated with Lp (a). The presence of the rs4684847 T allele (CT+TT) have a lower level of Lp (a) than the allele (CC) in the dominant model, mean difference was-27. 30 (95%CI:-52. 88~-1. 73) mg/L, P<0. 05. G-P-T and G-A-T HAPLOTYPE were associated with lower levels of Lp (a) (P=0. 0041 and<0. 0001), mean difference was 49. 79(95%CI:-97. 52~-2. 06) mg/L and 17. 75(95%CI:-25. 75~-9. 75) mg/L. Conclusion: PPAR GAMMA POLYMORPHISMs (rs10865710, rs1805192, rs4684847) and HAPLOTYPEs may be the genetic risk factors for Lp (a) level.

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    • Cite

    APA: Copy

    SHEN, CHAO, FAN, WEI, XIE, HUIJIAN, WU, MING, ZHOU, ZHENG YUAN, GUO, ZHI RONG, & DONG, CHEN. (2018). HAPLOTYPE ANALYSIS OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR γ GENE POLYMORPHISMS AND THE LIPOPROTEIN (A) LEVEL. IRANIAN JOURNAL OF PUBLIC HEALTH, 47(7), 973-979. SID. https://sid.ir/paper/274841/en

    Vancouver: Copy

    SHEN CHAO, FAN WEI, XIE HUIJIAN, WU MING, ZHOU ZHENG YUAN, GUO ZHI RONG, DONG CHEN. HAPLOTYPE ANALYSIS OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR γ GENE POLYMORPHISMS AND THE LIPOPROTEIN (A) LEVEL. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2018;47(7):973-979. Available from: https://sid.ir/paper/274841/en

    IEEE: Copy

    CHAO SHEN, WEI FAN, HUIJIAN XIE, MING WU, ZHENG YUAN ZHOU, ZHI RONG GUO, and CHEN DONG, “HAPLOTYPE ANALYSIS OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR γ GENE POLYMORPHISMS AND THE LIPOPROTEIN (A) LEVEL,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 47, no. 7, pp. 973–979, 2018, [Online]. Available: https://sid.ir/paper/274841/en

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