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Information Journal Paper

Title

Adiponectin: An Indicator for Metabolic Syndrome

Pages

  1106-1115

Abstract

 Background: Metabolic syndrome (MetS), a cluster of cardiometabolic risk factors, consider as a manifestation of obesity. However, a proportion of obese patients do not develop MetS. The aim of our study was to deter-mine whether concentration of plasma Adiponectin and Leptin differ between metabolic unhealthy obese (MUO) patients and comparable age-and sex-matched control groups. Methods: In this case-control study, we assigned 51 obese patients with MetS (MUO) in cases group and 102 metabolic healthy obese (MHO) and normal weight metabolic healthy subjects matched for age and gender to cases in control groups. The study was conducted between December 2014 and February 2016 in the Endocri-nology Research Center of Tehran University of Medical Sciences, Tehran, Iran. We measured serum adi-ponectin, Leptin, their ratio, and body composition in all subjects. Results: No significant differences were observed between MHO and MUO in term of total Fat mass and trunk fat (P>0. 05). Compared to MHO and normal weight metabolic healthy subjects, MUO subjects had low-er levels of plasma Adiponectin (P<0. 001) and lower plasma Adiponectin to Leptin ratio (P<0. 001) and a higher level of plasma Leptin (P<0. 002). A Receiver Operator Characteristic curve was used to identify the ability of Adiponectin and Leptin level to predict the MetS. The area under the Receiver Operator Characteristic curve was 0. 66 (P<0. 01), 0. 73 (P<0. 001) and 0. 75 (P<0. 001) for Leptin, Adiponectin, and Adiponectin/Leptin ratio levels respectively. Conclusion: Our study introduced Adiponectin and Leptin as indicator of MetS and obesity respectively.

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    APA: Copy

    YOSAEE, SOMAYE, KHODADOST, MAHMOUD, ESTEGHAMATI, ALIREZA, SPEAKMAN, JOHN R., DJAFARIAN, KUROSH, BITARAFAN, Vida, & SHIDFAR, FARZAD. (2019). Adiponectin: An Indicator for Metabolic Syndrome. IRANIAN JOURNAL OF PUBLIC HEALTH, 48(6), 1106-1115. SID. https://sid.ir/paper/274959/en

    Vancouver: Copy

    YOSAEE SOMAYE, KHODADOST MAHMOUD, ESTEGHAMATI ALIREZA, SPEAKMAN JOHN R., DJAFARIAN KUROSH, BITARAFAN Vida, SHIDFAR FARZAD. Adiponectin: An Indicator for Metabolic Syndrome. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2019;48(6):1106-1115. Available from: https://sid.ir/paper/274959/en

    IEEE: Copy

    SOMAYE YOSAEE, MAHMOUD KHODADOST, ALIREZA ESTEGHAMATI, JOHN R. SPEAKMAN, KUROSH DJAFARIAN, Vida BITARAFAN, and FARZAD SHIDFAR, “Adiponectin: An Indicator for Metabolic Syndrome,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 48, no. 6, pp. 1106–1115, 2019, [Online]. Available: https://sid.ir/paper/274959/en

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