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Information Journal Paper

Title

BIOEQUIVALENCE STUDY OF ATENOLOL: PHARMACOKINETIC AND PHARMACODYNAMIC EVALUATION

Pages

  95-98

Abstract

 This study was designed to assess pharmacokinetic parameters and pattern of pharmacodynamic effects (heart rate and BLOOD PRESSURE) of 100 mg ATENOLOL tablets in comparison with those of 100 mg Tenormin tablets as reference. A double blind cross over study was carried out among 12 healthy male subjects. A HPLC system using RP-C18 column and fluorescence detector was used to assess ATENOLOL in plasma. Heart r ate and blood p pressure was measured by the t rained clinic staff. Peak levels were observed about 2.97h for ATENOLOL and 3.73h for Tenormin after oral dosing. Cmax values for both formulations were about 0.49 µg/ml. AUC0-24was about 4.89 µg.h/ml for the test and 5.31 µg.h/ml for the reference group. ATENOLOL given orally caused a significant reduction in HEART RATE, systolic and diastolic BLOOD PRESSURE after administration of two formulations (P<0.05). It is concluded that two formulations are not significantly different in terms of pharmacodynamic and pharmacokinetic parameters which were studied.  

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    APA: Copy

    MIR FAZAELIAN, A., TABATABAEIFAR, M., REZAEI, SAEID, & MAHMOUDIAN, M.. (2003). BIOEQUIVALENCE STUDY OF ATENOLOL: PHARMACOKINETIC AND PHARMACODYNAMIC EVALUATION. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 11(3), 95-98. SID. https://sid.ir/paper/275179/en

    Vancouver: Copy

    MIR FAZAELIAN A., TABATABAEIFAR M., REZAEI SAEID, MAHMOUDIAN M.. BIOEQUIVALENCE STUDY OF ATENOLOL: PHARMACOKINETIC AND PHARMACODYNAMIC EVALUATION. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2003;11(3):95-98. Available from: https://sid.ir/paper/275179/en

    IEEE: Copy

    A. MIR FAZAELIAN, M. TABATABAEIFAR, SAEID REZAEI, and M. MAHMOUDIAN, “BIOEQUIVALENCE STUDY OF ATENOLOL: PHARMACOKINETIC AND PHARMACODYNAMIC EVALUATION,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 11, no. 3, pp. 95–98, 2003, [Online]. Available: https://sid.ir/paper/275179/en

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