مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Cites:

1

Information Journal Paper

Title

SOLVENT-DETERGENT TREATMENT OF IGM-ENRICHED IMMUNOGLOBULIN

Pages

  47-51

Abstract

 Viral safety of human plasma products plays a key role in their safe uses. Solvent- detergent (SD) virus-inactivation method has gained widespread popularity in the manufacture of biological products. This treatment which inactivates lipid-enveloped viruses effectively consists of incubation of a plasma protein solution in the presence of a non-volatile organic solvent and a detergent. In this study, IGM-enriched immunoglobulin was incubated at 24 °C for 6 h under slow stirring in the presence of tri(nbutyl) phosphate (0.3% w/w ) as solvent and TWEEN 80 (1% w/w) as detergent. After completion of the inactivation process and removal of the SOLVENT-DETERGENT, the ability of SD-treatment to remove Infectious Bovine Rhinotracheitis (IBR) virus (a lipid-enveloped virus) and Foot-and-Mouth Disease virus (a non-enveloped virus) were evaluated by virus spiking studies using a scaled down process. Reduction factor of 4 log was obtained for the SD-treatment of IGM-enriched immunoglobulin spiked with IBR virus. No VIRUS INACTIVATION was observed in the SD-treated IGM-enriched immunoglobulin, spiked with Foot-and-Mouth Disease virus. It was concluded that treatment of IGM-enriched immunoglobulin with TNBP-TWEEN 80 may be considered as an efficient lipid-enveloped VIRUS INACTIVATION step in the manufacture of this product.

Cites

References

Cite

APA: Copy

POURMOKHTAR, M., DINARVAND, R., MOUSAVI HOSSEINI, K., REZVAN, H., & JALILI, M.A.. (2003). SOLVENT-DETERGENT TREATMENT OF IGM-ENRICHED IMMUNOGLOBULIN. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 11(2), 47-51. SID. https://sid.ir/paper/275191/en

Vancouver: Copy

POURMOKHTAR M., DINARVAND R., MOUSAVI HOSSEINI K., REZVAN H., JALILI M.A.. SOLVENT-DETERGENT TREATMENT OF IGM-ENRICHED IMMUNOGLOBULIN. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2003;11(2):47-51. Available from: https://sid.ir/paper/275191/en

IEEE: Copy

M. POURMOKHTAR, R. DINARVAND, K. MOUSAVI HOSSEINI, H. REZVAN, and M.A. JALILI, “SOLVENT-DETERGENT TREATMENT OF IGM-ENRICHED IMMUNOGLOBULIN,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 11, no. 2, pp. 47–51, 2003, [Online]. Available: https://sid.ir/paper/275191/en

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