THE USE OF THERMORESPONSIVE HYDROGEL MEMBRANE AS MODULATED DRUG DELIVERY SYSTEM

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DINARVAND R.; ANSARI M.

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Journal Paper

Paper Information

Journal: DARU Journal of Pharmaceutical Sciences Year:2002 | Volume:10 | Issue:3 Page(s): 105-110

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Title

THE USE OF THERMORESPONSIVE HYDROGEL MEMBRANE AS MODULATED DRUG DELIVERY SYSTEM

Author(s)

DINARVAND R. | ANSARI M. | Issue Writer Certificate

Keywords

THERMOSENSITIVE HYDROGELS

MEMBRANES

HYDROXYUREA

ERYTHROMYCIN

POLY NIPAAM

COPOLY NIPAAM/AAM

Abstract

Stimuli-sensitive polymers are suitable candidates for novel drug delivery systems, since they release drugs in a controlled manner in response to a stimulus such as temperature. In the present study temperature-sensitive polymer of N-isopropylacryamide (NIPAAm) was evaluated to modulate release of drugs with different molecular weights. MEMBRANES of POLY NIPAAM and its copolymers with acryl amide (AAm) were prepared by casting monomers, cross linker, and initiator between two glass plates with a defined spacer thickness. These thermo sensitive hydrogels that cross linked with N,N-methylene-bis-acrylamide (MBAAm) showed a swelling transition temperatures (37°C) that was used in the permeation control of hydroxy urea (HU) and ERYTHROMYCIN (Er). Permeation rates of the drugs in various temperatures were investigated. It was shown that the diffusion rate of HU and Er through MEMBRANES is increased with a decrease in temperature. This phenomenon may be explained by the swelling (hydration) properties of the polymers and the thermodynamic influence of temperature and may be used as on-off switching key for controlled release of different molecules.

Cites

PREPARATION AND INVESTIGATION OF POLY (N-ISOPROPYL ACRYLAMIDE-ACRYLAMIDE) MEMBRANES IN TEMPERATURE RESPONSIVE DRUG DELIVERY

References

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APA: Copy

DINARVAND, R., & ANSARI, M.. (2002). THE USE OF THERMORESPONSIVE HYDROGEL MEMBRANE AS MODULATED DRUG DELIVERY SYSTEM. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 10(3), 105-110. SID. https://sid.ir/paper/275255/en

Vancouver: Copy

DINARVAND R., ANSARI M.. THE USE OF THERMORESPONSIVE HYDROGEL MEMBRANE AS MODULATED DRUG DELIVERY SYSTEM. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2002;10(3):105-110. Available from: https://sid.ir/paper/275255/en

IEEE: Copy

R. DINARVAND, and M. ANSARI, “THE USE OF THERMORESPONSIVE HYDROGEL MEMBRANE AS MODULATED DRUG DELIVERY SYSTEM,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 10, no. 3, pp. 105–110, 2002, [Online]. Available: https://sid.ir/paper/275255/en

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