THE INFLUENCE OF LIPID COMPOSITION AND CAROTENE ON LIPID PEROXIDATION IN LIPOSOMES

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SAR BOLOUKI M.N.; MAGHDOONI BAGHERI P.; SANI V.

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Journal Paper

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Journal: DARU Journal of Pharmaceutical Sciences Year:2005 | Volume:13 | Issue:4 Page(s): 147-154

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Information Journal Paper

Title

THE INFLUENCE OF LIPID COMPOSITION AND CAROTENE ON LIPID PEROXIDATION IN LIPOSOMES

Author(s)

SAR BOLOUKI M.N. | MAGHDOONI BAGHERI P. | SANI V. | Issue Writer Certificate

Keywords

CAROTENE

LIPOSOMES

LIPID PEROXIDATION

ERYTHROCYTE PHOSPHOLIPIDS

IRON-INDUCED PEROXIDATION

EGG YOLK PHOSPHOLIPIDS

ANTIOXIDANT

Abstract

Oxidative damage to membrane lipid is one of the prime events occurring in aging and other undesirable physiological processes. In this study experiments were performed on LIPOSOMES (prepared either from crude ERYTHROCYTE PHOSPHOLIPIDS or purified egg yolk phosphatidylcholine) as models of lipid bilayer portion of biomembranes. The effects of β-carotene, and phospholipid composition on peroxidation process, initiated by Fe2+, were studied. It was found that β-CAROTENE does not show any noticeable ANTIOXIDANT effect on the peroxidation process initiated by Fe2+ in LIPOSOMES prepared from erythrocyte phosphatides, whereas it effectively suppressed the same process in egg yolk phosphatidylcholine (EYPC). It is concluded that the anti-/pro-oxidant activity of β–CAROTENE is also dependent on the membrane lipid composition and this may provide an explanation about the conflicting reports on its role in ordinary or promoted oxidation experiments.

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APA: Copy

SAR BOLOUKI, M.N., MAGHDOONI BAGHERI, P., & SANI, V.. (2005). THE INFLUENCE OF LIPID COMPOSITION AND CAROTENE ON LIPID PEROXIDATION IN LIPOSOMES. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 13(4), 147-154. SID. https://sid.ir/paper/275315/en

Vancouver: Copy

SAR BOLOUKI M.N., MAGHDOONI BAGHERI P., SANI V.. THE INFLUENCE OF LIPID COMPOSITION AND CAROTENE ON LIPID PEROXIDATION IN LIPOSOMES. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2005;13(4):147-154. Available from: https://sid.ir/paper/275315/en

IEEE: Copy

M.N. SAR BOLOUKI, P. MAGHDOONI BAGHERI, and V. SANI, “THE INFLUENCE OF LIPID COMPOSITION AND CAROTENE ON LIPID PEROXIDATION IN LIPOSOMES,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 13, no. 4, pp. 147–154, 2005, [Online]. Available: https://sid.ir/paper/275315/en

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