EVALUATION OF THE EFFECT OF ANETHUM GRAVEOLENS L. CRUDE EXTRACTS ONSERUM LIPIDS AND LIPOPROTEINS PROFILES IN HYPERCHOLESTEROLAEMIC RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

YAZDAN PARAST R.; BAHRAMIKIA S.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: DARU Journal of Pharmaceutical Sciences Year:2008 | Volume:16 | Issue:2 Page(s): 88-94

Download Full-Text

View:

560

Download:

522

Cites:

Information Journal Paper

Title

EVALUATION OF THE EFFECT OF ANETHUM GRAVEOLENS L. CRUDE EXTRACTS ONSERUM LIPIDS AND LIPOPROTEINS PROFILES IN HYPERCHOLESTEROLAEMIC RATS

Author(s)

YAZDAN PARAST R. | BAHRAMIKIA S. | Issue Writer Certificate

Keywords

ANETHUM GRAVEOLENS

HYPERCHOLESTEROLAEMIC RATS

HYPOLIPIDAEMIC PROPERTY

HMG-COA REDUCTASE

FLAVONOIDS CONTENT

Abstract

Background and the purpose of study: ANETHUM GRAVEOLENS L. (Umbilliferae) is used in Iranian folk medicine as an anti-hypercholesterolaemic plant. The present study was carried out to determine the effect of ANETHUM GRAVEOLENS extract (AGE) on serum lipoproteins in HYPERCHOLESTEROLAEMIC RATS and also to determine its mechanism of action to some extant on liver hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase activity.Methods: The changes in serum triglyceride (TG), total cholesterol (TC), high density lipoprotein-cholesterol (HDL-C) and low density lipoprotein-cholesterol (LDL-C) were measured using enzymatic kits. Hepatic HMG-COA REDUCTASE activity was indirectly measured by the HMG CoA/mevalonate ratio. The amount of total phenolic and flavonoid compounds were also determined by common colorimetric methods.Results: Keeping the rats on a high-fat diet for 7 consecutive days increased the serum TC, TG and LDL-C levels significantly. However, the HDL-C level decreased relative to normal rats. Treatment of hyperlipidaemic rats with AGE (single daily dose of 1 ml, equivalent to 500 mg of the plant powder) and high-fat diet for up to 10 and/or 30 days reversed the serum lipid levels compared to rats which were fed only high-fat diet. In addition, our data indicated significant increase in HMG-CoA/mevalonate ratio as compared to rats which were fed high-fat diet after treatment with AGE for 30 days, indicating a decrease in the enzyme activity. Experiments showed that AGE has the phenolic and flavonoid content of 105.2 mg of gallic acid equivalents/g of the dried extract and 58.2 mg of catechin equivalents/g of the dried extract, respectively.Conclusion: The cumulative results clearly indicate that A. graveolens possesses potent hypocholesterolaemic effects in rats probably mediated through the suppression of endogenous cholesterol biosynthesis by inhibition of the activity of HMG-COA REDUCTASE.

Cites

No record.

References

Cite

APA: Copy

YAZDAN PARAST, R., & BAHRAMIKIA, S.. (2008). EVALUATION OF THE EFFECT OF ANETHUM GRAVEOLENS L. CRUDE EXTRACTS ONSERUM LIPIDS AND LIPOPROTEINS PROFILES IN HYPERCHOLESTEROLAEMIC RATS. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 16(2), 88-94. SID. https://sid.ir/paper/275454/en

Vancouver: Copy

YAZDAN PARAST R., BAHRAMIKIA S.. EVALUATION OF THE EFFECT OF ANETHUM GRAVEOLENS L. CRUDE EXTRACTS ONSERUM LIPIDS AND LIPOPROTEINS PROFILES IN HYPERCHOLESTEROLAEMIC RATS. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2008;16(2):88-94. Available from: https://sid.ir/paper/275454/en

IEEE: Copy

R. YAZDAN PARAST, and S. BAHRAMIKIA, “EVALUATION OF THE EFFECT OF ANETHUM GRAVEOLENS L. CRUDE EXTRACTS ONSERUM LIPIDS AND LIPOPROTEINS PROFILES IN HYPERCHOLESTEROLAEMIC RATS,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 16, no. 2, pp. 88–94, 2008, [Online]. Available: https://sid.ir/paper/275454/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops