PH-INDEPENDENT RELEASE OF PROPRANOLOL HYDROCHLORIDE FROM HPMCBASED MATRICES USING ORGANIC ACIDS

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BOLOUR CHIAN N.; DADASHZADEH S.

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Paper Information

Journal: DARU Journal of Pharmaceutical Sciences Year:2008 | Volume:16 | Issue:3 Page(s): 136-142

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Information Journal Paper

Title

PH-INDEPENDENT RELEASE OF PROPRANOLOL HYDROCHLORIDE FROM HPMCBASED MATRICES USING ORGANIC ACIDS

Author(s)

BOLOUR CHIAN N. | DADASHZADEH S. | Issue Writer Certificate

Keywords

PROPRANOLOL HCL

PH-INDEPENDENT RELEASE

HPMC MATRICES

ORGANIC ACIDS

Abstract

Background and purpose of the study: PROPRANOLOL HCL, a widely used drug in the treatment of cardiac arrhythmias and hypertension, is a weak basic drug with pH-dependent solubility that may show release problems from sustained release dosage forms at higher pH of small intestine. This might decrease drug bioavailability and cause variable oral absorption. Preparation of a sustained release matrix system with a pH–independent release profile was the aim of the present study. Methods: Three types of ORGANIC ACIDS namely tartaric, citric and fumaric acid in the concentrations of 5, 10 and 15% were added to the matrices prepared by hydroxypropyl methylcellulose (HPMC) and dicalcium phosphate. The drug release studies were carried out at pH 1.2 and pH 6.8 separately and mean dissolution time (MDT) as well as similarity factor (ƒ2) were calculated for all formulations. Results and discussion: It was found that incorporation of 5 and 10 % tartaric acid in tablet formulations with 30% HPMC resulted in a suitable PH-INDEPENDENT RELEASE profiles with significant higher ƒ2 values (89.9 and 87.6 respectively) compared to acid free tablet (58.03). The other two acids did not show the desirable effects. It seems that lower pKa of tartaric acid accompanied by its higher solubility were the main factors in the achievement of PH-INDEPENDENT RELEASE profiles.

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APA: Copy

BOLOUR CHIAN, N., & DADASHZADEH, S.. (2008). PH-INDEPENDENT RELEASE OF PROPRANOLOL HYDROCHLORIDE FROM HPMCBASED MATRICES USING ORGANIC ACIDS. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 16(3), 136-142. SID. https://sid.ir/paper/275462/en

Vancouver: Copy

BOLOUR CHIAN N., DADASHZADEH S.. PH-INDEPENDENT RELEASE OF PROPRANOLOL HYDROCHLORIDE FROM HPMCBASED MATRICES USING ORGANIC ACIDS. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2008;16(3):136-142. Available from: https://sid.ir/paper/275462/en

IEEE: Copy

N. BOLOUR CHIAN, and S. DADASHZADEH, “PH-INDEPENDENT RELEASE OF PROPRANOLOL HYDROCHLORIDE FROM HPMCBASED MATRICES USING ORGANIC ACIDS,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 16, no. 3, pp. 136–142, 2008, [Online]. Available: https://sid.ir/paper/275462/en

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