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Information Journal Paper

Title

EFFECTS OF HYDROALCOHOLIC EXTRACT OF CYNODON DACTYLON (L.) PERS. ON ISCHEMIA/REPERFUSION-INDUCED ARRHYTHMIAS

Pages

  233-238

Keywords

CYNODON DACTYLON (L.) PERS. 
RAT 

Abstract

 Background and purpose of the study: Probable antiarrhythmic effects of Cynodon dactylon (L.) pers. (family Poaceae) against ISCHEMIA/reperfusion (I/R)-induced ARRHYTHMIAS were investigated in isolated RAT heart. Methods: The hearts were subjected to 30min regional ISCHEMIA followed by 30min REPERFUSION and perfused with hydroalcoholic extract of rhizome of C. dactylon (25, 50, 100 and 200μg/ml). Results: During ISCHEMIA, the extract produced marked reduction in the number, duration and incidences of ventricular tachycardia (VT) at 25 and 50mg/ml (p<0.001 and p<0.01, respectively). Total number of ischemic ventricular ectopic beats (VEBs) were lowered by 25-100mg/ml (p<0.001, p<0.001 and p<0.05, respectively). At the REPERFUSION phase, C. dactylon (25 and 50mg/ml) decreased incidence of VT from 100% (control) to 13 and 33% (p<0.001 and p<0.05) respectively. Duration and number of VT and total VF incidence were also reduced at the same concentration (p<0.05 for all). Perfusion of the extract (25- 100mg/ml) was markedly lowered reversible VF duration from 218±99sec to 0 sec, 0 sec and 10±5sec (p<0.01, p<0.01 and p<0.05) respectively. Moreover, C. dactylon (25 and 50mg/ml) decreased number of total VEBs from 349±73 to 35±17 (p<0.001) and 66±26 (p<0.01). In this study, it was also shown that perfusion of the extract produced a marked and concentration-dependent positive inotropic effect. Conclusion: The findings of this study indicate that C. dactylon produce protective effects against I/R-induced ARRHYTHMIAS in isolated RAT hearts probably by increase in the myocardial contractility and as a result by improvement of hemodynamic factors.

Cites

References

Cite

APA: Copy

NAJAFI, M., NAZEMIEH, H., GHAVIMI, H., GHARAHKHANI, A., & GARJANI, A.. (2008). EFFECTS OF HYDROALCOHOLIC EXTRACT OF CYNODON DACTYLON (L.) PERS. ON ISCHEMIA/REPERFUSION-INDUCED ARRHYTHMIAS. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 16(4), 233-238. SID. https://sid.ir/paper/275476/en

Vancouver: Copy

NAJAFI M., NAZEMIEH H., GHAVIMI H., GHARAHKHANI A., GARJANI A.. EFFECTS OF HYDROALCOHOLIC EXTRACT OF CYNODON DACTYLON (L.) PERS. ON ISCHEMIA/REPERFUSION-INDUCED ARRHYTHMIAS. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2008;16(4):233-238. Available from: https://sid.ir/paper/275476/en

IEEE: Copy

M. NAJAFI, H. NAZEMIEH, H. GHAVIMI, A. GHARAHKHANI, and A. GARJANI, “EFFECTS OF HYDROALCOHOLIC EXTRACT OF CYNODON DACTYLON (L.) PERS. ON ISCHEMIA/REPERFUSION-INDUCED ARRHYTHMIAS,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 16, no. 4, pp. 233–238, 2008, [Online]. Available: https://sid.ir/paper/275476/en

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