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Information Journal Paper

Title

FLOW CYTOMETRY SUSCEPTIBILITY TESTING FOR CONVENTIONAL ANTIFUNGAL DRUGS AND COMPARISON WITH THE NCCLS BROTH MACRO DILUTION TEST

Pages

  94-98

Abstract

 Introduction: During the last decade, the incidence of fungal infection has been increased in many countries. Because of the advent of resistant to antifungal agents, determination of an efficient strategic plan for treatment of fungal disease is an important issue in clinical mycology. Many methods have been introduced and developed for determination of invitro SUSCEPTIBILITY tests. During the recent years, FLOW CYTOMETRY has developed to solving the problem and many papers have documented the usefulness of this technique.Materials and methods: As the first step, the invitro SUSCEPTIBILITY of standard PTCC (Persian Type of Culture Collection) strain and some clinical isolates of Candida consisting of Candida albicans, C. dubliniensis, C. glabrata, C. kefyer and C. parapsilosis were evaluated by MACRODILUTION broth method according to NCCLS (National Committee for Clinical Laboratory Standards) guidelines and FLOW CYTOMETRY SUSCEPTIBILITY test.Results: The data indicated that macro dilution broth methods and FLOW CYTOMETRY have the same results in determination of MIC (Minimum Inhibitory Concentration) for amphotericin B, clotrimazole, fluconazole, ketoconazole and miconazole in C. albicans PTCC 5027 as well as clinical Candida isolates, such as C.albicans, C.dubliniensis, C.glabrata C.kefyr, and C.parapsilosis.Discussion: Comparing the results obtained by macro dilution broth and FLOW CYTOMETRY methods revealed that FLOW CYTOMETRY was faster. It is suggested that FLOW CYTOMETRYsusceptibility test can be used as a powerful tool for determination of MIC and administration of the best antifungal drug in treatment of patients with Candida infections.

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    APA: Copy

    NAJAFZADEH, M.J., FALAHATI, M., POUSHANGA BAGHERI, K., FATA, A., & FATEH, R.. (2009). FLOW CYTOMETRY SUSCEPTIBILITY TESTING FOR CONVENTIONAL ANTIFUNGAL DRUGS AND COMPARISON WITH THE NCCLS BROTH MACRO DILUTION TEST. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 17(2), 94-98. SID. https://sid.ir/paper/275505/en

    Vancouver: Copy

    NAJAFZADEH M.J., FALAHATI M., POUSHANGA BAGHERI K., FATA A., FATEH R.. FLOW CYTOMETRY SUSCEPTIBILITY TESTING FOR CONVENTIONAL ANTIFUNGAL DRUGS AND COMPARISON WITH THE NCCLS BROTH MACRO DILUTION TEST. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2009;17(2):94-98. Available from: https://sid.ir/paper/275505/en

    IEEE: Copy

    M.J. NAJAFZADEH, M. FALAHATI, K. POUSHANGA BAGHERI, A. FATA, and R. FATEH, “FLOW CYTOMETRY SUSCEPTIBILITY TESTING FOR CONVENTIONAL ANTIFUNGAL DRUGS AND COMPARISON WITH THE NCCLS BROTH MACRO DILUTION TEST,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 17, no. 2, pp. 94–98, 2009, [Online]. Available: https://sid.ir/paper/275505/en

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